ID   PFMAC_PESFW             Reviewed;         530 AA.
AC   W3X9K4;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=MFS transporter PfmaC {ECO:0000303|PubMed:28517364};
DE   AltName: Full=Conidial pigment biosynthesis cluster protein B {ECO:0000303|PubMed:28517364};
GN   Name=PfmaC {ECO:0000303|PubMed:28517364}; ORFNames=PFICI_07099;
OS   Pestalotiopsis fici (strain W106-1 / CGMCC3.15140).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Sporocadaceae; Pestalotiopsis.
OX   NCBI_TaxID=1229662;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W106-1 / CGMCC3.15140;
RX   PubMed=25623211; DOI=10.1186/s12864-014-1190-9;
RA   Wang X., Zhang X., Liu L., Xiang M., Wang W., Sun X., Che Y., Guo L.,
RA   Liu G., Guo L., Wang C., Yin W.B., Stadler M., Zhang X., Liu X.;
RT   "Genomic and transcriptomic analysis of the endophytic fungus
RT   Pestalotiopsis fici reveals its lifestyle and high potential for synthesis
RT   of natural products.";
RL   BMC Genomics 16:28-28(2015).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION.
RX   PubMed=28517364; DOI=10.1111/mmi.13711;
RA   Zhang P., Wang X., Fan A., Zheng Y., Liu X., Wang S., Zou H., Oakley B.R.,
RA   Keller N.P., Yin W.B.;
RT   "A cryptic pigment biosynthetic pathway uncovered by heterologous
RT   expression is essential for conidial development in Pestalotiopsis fici.";
RL   Mol. Microbiol. 105:469-483(2017).
CC   -!- FUNCTION: MFS transporter; part of the gene cluster that mediates the
CC       biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green
CC       pigment forming a dark layer in the conidial wall that protects the
CC       conidia from UV radiations. {ECO:0000269|PubMed:28517364}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is positively regulazed by the cluster-specific
CC       transcription factor pfmaF. {ECO:0000269|PubMed:28517364}.
CC   -!- DISRUPTION PHENOTYPE: Does not affect the production of scytalone.
CC       {ECO:0000269|PubMed:28517364}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Allantoate
CC       permease family. {ECO:0000305}.
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DR   EMBL; KI912112; ETS82097.1; -; Genomic_DNA.
DR   RefSeq; XP_007833871.1; XM_007835680.1.
DR   AlphaFoldDB; W3X9K4; -.
DR   SMR; W3X9K4; -.
DR   EnsemblFungi; ETS82097; ETS82097; PFICI_07099.
DR   GeneID; 19272112; -.
DR   KEGG; pfy:PFICI_07099; -.
DR   eggNOG; KOG2533; Eukaryota.
DR   HOGENOM; CLU_001265_4_2_1; -.
DR   OMA; WMNTYFN; -.
DR   OrthoDB; 497052at2759; -.
DR   Proteomes; UP000030651; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Melanin biosynthesis; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..530
FT                   /note="MFS transporter PfmaC"
FT                   /id="PRO_0000445351"
FT   TRANSMEM        165..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        324..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        456..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        493..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          41..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   530 AA;  58401 MW;  7281BAD17CCF0A70 CRC64;
     MSGPALEVAA AKTAEQGQVP VLAAAVRGDT KVSGDSIHAA TTAVSDGDNQ SSTMSGKTAA
     GDATSPASGS GSGGWFHWHE PGTSKAEKKL IFKLDWFLLS YSCLCFFIKQ LDGNNVTNAY
     ASGMQEQLGF GPGNELSWMN TYFNIGQIIG APFANMIITV VRPRYWLPAC LMTWSAFVLG
     MYRCETAAQF YVLRFFIGLF EGAAWPGITY TLGCWYRKSE MARRSALFVM SGVLGQMFSG
     YLQAALYTGM DGKGGLAAWR WLFIFDFILA VPIAIYGLFC FPDTPHKTSA WYLNSWEREK
     AVERIDSEGR KPIGKLDLSV FKRIFTSWQV YAFTLGYALW SLTVGSYVMQ YFTLYLKATK
     EYTIPQINNI PTALGAVNFV TMLTTGFVSD KIGRRGPVCL AVGCVLIFTY SIFTAWNVPH
     RLLMAVFILN GVYGCYTPLL AGWVNECCGG DQQKRAFILG LMTSVGGAVV IPFQQLQFPS
     SQAPQFKQTH GWPSALAFVI ALTCWTGLGI PLLQRRMEKQ AKRNEAEHEA