PFMAH_PESFW
ID PFMAH_PESFW Reviewed; 958 AA.
AC W3X9K7;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 19-MAR-2014, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=Transcription factor PfmaH {ECO:0000303|PubMed:28517364};
DE AltName: Full=Conidial pigment biosynthesis cluster protein H {ECO:0000303|PubMed:28517364};
GN Name=PfmaH; ORFNames=PFICI_07104;
OS Pestalotiopsis fici (strain W106-1 / CGMCC3.15140).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Sporocadaceae; Pestalotiopsis.
OX NCBI_TaxID=1229662;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W106-1 / CGMCC3.15140;
RX PubMed=25623211; DOI=10.1186/s12864-014-1190-9;
RA Wang X., Zhang X., Liu L., Xiang M., Wang W., Sun X., Che Y., Guo L.,
RA Liu G., Guo L., Wang C., Yin W.B., Stadler M., Zhang X., Liu X.;
RT "Genomic and transcriptomic analysis of the endophytic fungus
RT Pestalotiopsis fici reveals its lifestyle and high potential for synthesis
RT of natural products.";
RL BMC Genomics 16:28-28(2015).
RN [2]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION, AND PATHWAY.
RX PubMed=28517364; DOI=10.1111/mmi.13711;
RA Zhang P., Wang X., Fan A., Zheng Y., Liu X., Wang S., Zou H., Oakley B.R.,
RA Keller N.P., Yin W.B.;
RT "A cryptic pigment biosynthetic pathway uncovered by heterologous
RT expression is essential for conidial development in Pestalotiopsis fici.";
RL Mol. Microbiol. 105:469-483(2017).
RN [3]
RP DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=31116900; DOI=10.1111/mmi.14281;
RA Zhang P., Zhou S., Wang G., An Z., Liu X., Li K., Yin W.B.;
RT "Two transcription factors cooperatively regulate DHN melanin biosynthesis
RT and development in Pestalotiopsis fici.";
RL Mol. Microbiol. 112:649-666(2019).
CC -!- FUNCTION: Transcription factor; part of the gene cluster that mediates
CC the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green
CC pigment forming a dark layer in the conidial wall that protects the
CC conidia from UV radiations (PubMed:28517364). The 2 transcription
CC factors present in the cluster, PfmaF and PfmaH, coordinately regulate
CC DHN-melanin production (PubMed:31116900). PfmaH acts as a pathway
CC specific regulator to mediate the expression of Pfma cluster genes
CC including PfmaJ, leading to DHN-melanin production in conidia, and
CC regulates the conidial formation (PubMed:31116900).
CC {ECO:0000269|PubMed:28517364, ECO:0000269|PubMed:31116900}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- INDUCTION: Expression is positively regulazed by the cluster-specific
CC transcription factor pfmaF. {ECO:0000269|PubMed:28517364,
CC ECO:0000269|PubMed:31116900}.
CC -!- DISRUPTION PHENOTYPE: Leads to the accumulation of a large amount of
CC shunt product scytalone. {ECO:0000269|PubMed:28517364,
CC ECO:0000269|PubMed:31116900}.
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DR EMBL; KI912112; ETS82102.1; -; Genomic_DNA.
DR RefSeq; XP_007833876.1; XM_007835685.1.
DR AlphaFoldDB; W3X9K7; -.
DR STRING; 1229662.W3X9K7; -.
DR EnsemblFungi; ETS82102; ETS82102; PFICI_07104.
DR GeneID; 19272117; -.
DR KEGG; pfy:PFICI_07104; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_008362_0_0_1; -.
DR OMA; KWQMDIA; -.
DR OrthoDB; 271547at2759; -.
DR Proteomes; UP000030651; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Melanin biosynthesis; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..958
FT /note="Transcription factor PfmaH"
FT /id="PRO_0000445355"
FT DNA_BIND 44..70
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 272..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 958 AA; 106278 MW; 1ACC654D391BA55A CRC64;
MLMISNCSRD LLQRHFSNYH DPSASEAPVA GAGPSVAGKT PIACLNCSQA KTGCNKEVPC
QRCQDKGLHC VQRYARRTSK LAARSQAAAT AAAAQASRVA QVTPVTVQQS LPNVSVSIEP
SQTLSQIQPP LVHEGGASVT MDPAILEMPL MNSFMKQQDP EVHDGSSPAN SITFPLPIHL
KAESPRQRTA SVDLNFNNMN SEPSPPSIEP MEDQSWVNSL MSNDPNFGPG NMFSSTYDLG
YQLGPSYADP TTDFSQMSQS MLQHDASMSS MEFAGSPSGV SPFGDLSTSN SEPSSSSWGS
SHTRATSICS AHCLYDQSGE FDVTSNSAKQ GLPISTDSDV ILTEAAWPMA RCTPPIYSGA
CPRTALGHLQ RLEQKSSYQG ARPFAWHTLE RELSSLNWDN ADLASVVPMN SQTRDSLMSI
SQRFHARALD IHRENDPGRD KSPLGSNCGP MSFLNLPSSK VLEFFMKSYV RSLTSFYSLV
SEGRIDPNQM HRNDPASIIL MLLMIAQGAS AVDSEDARIL SMGLIETCRI SLLDIIDKNV
EMSADPTALR AALLFAHLGA WSGDKWLMDI AMGQRGMYIS MLKHAGMLTA QPPICPVLDG
DQGQKNSWRL WLQVETKNRL VYDWVMVDQE LSLFHDTDPQ LDVSELRASL PCSEKLWKSS
TVEQWADAVQ CYLSKGNPHP LTPPSLYHLY REFLEQKLVD GRVGLTAHQL RLLLHPIQKM
LCQQRQTLTC FSDMFVPDQP GHVSFSKAYV MRQVEVVRSL LSRWHDLAMR CLNMNPDCTI
MRTNMVLYHL ISLNAVTNFP EIESFARQER YDGSYWGSRH QRCIYNRQQA VHDCGQVFSI
LRNLPTDRLP TWWSAAIYRA TMILWADSAL QSQSQAHASL SPPEATEGQY AMNAPQDFNH
TLDYNVIPYV TRSDGTPFHL DRHSEVLDYA ICAIDQGASS RLGEGIKRKL IALGNNWH