ID   PFPA_RICCO              Reviewed;         617 AA.
AC   Q41140;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha {ECO:0000255|HAMAP-Rule:MF_03185};
DE            Short=PFP {ECO:0000255|HAMAP-Rule:MF_03185};
DE   AltName: Full=6-phosphofructokinase, pyrophosphate dependent {ECO:0000255|HAMAP-Rule:MF_03185};
DE   AltName: Full=PPi-PFK {ECO:0000255|HAMAP-Rule:MF_03185};
DE   AltName: Full=Pyrophosphate-dependent 6-phosphofructose-1-kinase {ECO:0000255|HAMAP-Rule:MF_03185};
GN   Name=PFP-ALPHA {ECO:0000255|HAMAP-Rule:MF_03185};
OS   Ricinus communis (Castor bean).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae;
OC   Ricinus.
OX   NCBI_TaxID=3988;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7835697; DOI=10.1016/0378-1119(94)00646-a;
RA   Todd J.F., Blakeley S.D., Dennis D.T.;
RT   "Structure of the genes encoding the alpha- and beta-subunits of castor
RT   pyrophosphate-dependent phosphofructokinase.";
RL   Gene 152:181-186(1995).
CC   -!- FUNCTION: Regulatory subunit of pyrophosphate--fructose 6-phosphate 1-
CC       phosphotransferase. {ECO:0000255|HAMAP-Rule:MF_03185}.
CC   -!- ACTIVITY REGULATION: Allosterically activated by fructose 2,6-
CC       bisphosphate. {ECO:0000255|HAMAP-Rule:MF_03185}.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 3/4.
CC       {ECO:0000255|HAMAP-Rule:MF_03185}.
CC   -!- SUBUNIT: Tetramer of two alpha (regulatory) and two beta (catalytic)
CC       chains. {ECO:0000255|HAMAP-Rule:MF_03185}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03185}.
CC   -!- SIMILARITY: Belongs to the phosphofructokinase type A (PFKA) family.
CC       PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03185}.
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DR   EMBL; Z32849; CAA83682.1; -; Genomic_DNA.
DR   PIR; T10102; T10102.
DR   AlphaFoldDB; Q41140; -.
DR   SMR; Q41140; -.
DR   STRING; 3988.XP_002510738.1; -.
DR   PRIDE; Q41140; -.
DR   eggNOG; KOG2440; Eukaryota.
DR   InParanoid; Q41140; -.
DR   UniPathway; UPA00109; UER00182.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003872; F:6-phosphofructokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0047334; F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.460; -; 1.
DR   HAMAP; MF_01980; Phosphofructokinase_II_Long; 1.
DR   InterPro; IPR011183; PfpB_PPi_PFK.
DR   InterPro; IPR000023; Phosphofructokinase_dom.
DR   InterPro; IPR035966; PKF_sf.
DR   Pfam; PF00365; PFK; 1.
DR   PIRSF; PIRSF005677; PPi_PFK_PfpB; 1.
DR   SUPFAM; SSF53784; SSF53784; 1.
DR   TIGRFAMs; TIGR02477; PFKA_PPi; 1.
PE   3: Inferred from homology;
KW   Allosteric enzyme; Cytoplasm; Glycolysis; Kinase; Magnesium; Metal-binding;
KW   Transferase.
FT   CHAIN           1..617
FT                   /note="Pyrophosphate--fructose 6-phosphate 1-
FT                   phosphotransferase subunit alpha"
FT                   /id="PRO_0000112047"
SQ   SEQUENCE   617 AA;  67361 MW;  1C9B2A0AF11FF3F0 CRC64;
     MDSDFGIPRE LSDLQKLRSL YKPELPPCLQ GTTVRVELGD GTTACSEAGA HTISRSFPHT
     YGQPLAHFLR ATAKVADAHI ISEHPAMRVG VVFCGRQSPG GHNVVWGLHN ALKIHNPNST
     LLGFLGGSEG LFAQKTLEVT DDILSTYKNQ GGYDLLGRTK DQIRTTEQVH AALTTCKNLK
     LDGLVIIGGV TSNTDAAQLA ETFAEAKCPT KVVGVPVTLN GDLKNQFVET NVGFDTICKV
     NSQLISNVCT DALSAEKYYY FIRLMGRKAS HVALECTLQS HPNMVILGEE VAASKLTLFD
     LTKQVCDAVQ ARAEQDKYHG VILLPEGLIE SIPEVYALLK EIHGLLRQGV SPNNISSQLS
     PWASALFEFL PPFIKKQLLL YPESDDSAQL SQIETEKLLA HLVEAEMNKR LKEGTYKGKK
     FNAICHFFGY QARGSLPSKF DCDYAYVLGH ICYHVLAAGL NGYMATATNL KNPVNKWRCG
     AAPIAAMMTV KRWAQNPGAT SIGKPAIHPA AVDLKGKAYE LLRLNAVKFL MDDLYRNPGP
     LQFEGPGADA KPITLCVEDQ DYMGRIKKLQ EYLDKVRTIV KPGCSQEVLK AALSVMASVT
     DVLLTMSSTS LDGQKPL