PFPB_ENTHI
ID PFPB_ENTHI Reviewed; 96 AA.
AC Q24824;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Pore-forming peptide ameobapore B;
DE AltName: Full=EH-APP;
DE Flags: Precursor;
OS Entamoeba histolytica.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=5759;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 20-63.
RC STRAIN=ATCC 30459 / HM-1:IMSS;
RX PubMed=7715451; DOI=10.1111/j.1365-2958.1994.tb01325.x;
RA Leippe M., Andrae J., Nickel R., Tannich E., Mueller-Eberhard H.J.;
RT "Amoebapores, a family of membranolytic peptides from cytoplasmic granules
RT of Entamoeba histolytica: isolation, primary structure, and pore formation
RT in bacterial cytoplasmic membranes.";
RL Mol. Microbiol. 14:895-904(1994).
CC -!- FUNCTION: Forms pores in the cytoplasmic membrane of host cells. Has
CC antibacterial activity against M.luteus, no activity against E.coli.
CC Implicated in the cytolytic activity of the parasite.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic granule.
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DR EMBL; X76904; CAA54226.1; -; Genomic_DNA.
DR PIR; S61440; S49144.
DR AlphaFoldDB; Q24824; -.
DR SMR; Q24824; -.
DR TCDB; 1.C.35.1.2; the amoebapore (amoebapore) family.
DR VEuPathDB; AmoebaDB:EHI5A_011850; -.
DR VEuPathDB; AmoebaDB:EHI7A_005290; -.
DR VEuPathDB; AmoebaDB:EHI8A_003320; -.
DR VEuPathDB; AmoebaDB:EHI_194540; -.
DR VEuPathDB; AmoebaDB:KM1_013430; -.
DR OMA; VCEKIHA; -.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR008138; SapB_2.
DR InterPro; IPR011001; Saposin-like.
DR InterPro; IPR008139; SaposinB_dom.
DR Pfam; PF03489; SapB_2; 1.
DR SMART; SM00741; SapB; 1.
DR SUPFAM; SSF47862; SSF47862; 1.
DR PROSITE; PS50015; SAP_B; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000269|PubMed:7715451"
FT PEPTIDE 20..96
FT /note="Pore-forming peptide ameobapore B"
FT /id="PRO_0000031669"
FT DOMAIN 20..96
FT /note="Saposin B-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT DISULFID 24..96
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT DISULFID 27..90
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT DISULFID 54..65
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
SQ SEQUENCE 96 AA; 10437 MW; 99E6AFADB02B42CC CRC64;
MRAIIFVLIF AIAFAATREG AILCNLCKDT VKLVENLLTV DGAQAVRQYI DNLCGKASGF
LGTLCEKILS FGVDELVKLI ENHVDPVVVC EKIHAC