ID   PFR2_TRYBB              Reviewed;         595 AA.
AC   Q26789; Q26790;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=73 kDa paraflagellar rod protein;
DE            Short=73 kDa PFR protein;
DE   AltName: Full=PFR-C/PFR-D;
GN   Name=PFRC;
GN   and
GN   Name=PFRD;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=STIB 366;
RX   PubMed=7961827; DOI=10.1016/s0021-9258(19)61968-x;
RA   Deflorin J., Rudolf M., Seebeck T.;
RT   "The major components of the paraflagellar rod of Trypanosoma brucei are
RT   two similar, but distinct proteins which are encoded by two different gene
RT   loci.";
RL   J. Biol. Chem. 269:28745-28751(1994).
CC   -!- FUNCTION: Major component of the paraflagellar rod (PFR). The PFR is a
CC       highly ordered lattices of fibrous proteins that are located inside the
CC       flagellum and assume a fixed orientation with respect to the
CC       microtubular axoneme.
CC   -!- SUBUNIT: Heterodimer of a 69 kDa and a 73 kDa protein.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum. Cytoplasm,
CC       cytoskeleton.
CC   -!- MISCELLANEOUS: Coded by two tandemly repeated genes with almost
CC       identical ORF: PFRC and PFRD.
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DR   EMBL; Z25827; CAA81068.1; -; Genomic_DNA.
DR   EMBL; Z25827; CAA81069.1; -; Genomic_DNA.
DR   PIR; S37057; S37057.
DR   AlphaFoldDB; Q26789; -.
DR   SMR; Q26789; -.
DR   PRIDE; Q26789; -.
DR   ABCD; Q26789; 1 sequenced antibody.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR007824; Flagellar_rod.
DR   Pfam; PF05149; Flagellar_rod; 1.
PE   4: Predicted;
KW   Calmodulin-binding; Cell projection; Cilium; Cytoplasm; Cytoskeleton;
KW   Flagellum.
FT   CHAIN           1..595
FT                   /note="73 kDa paraflagellar rod protein"
FT                   /id="PRO_0000058347"
FT   REGION          294..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          317..337
FT                   /note="Calmodulin-binding"
FT                   /evidence="ECO:0000255"
FT   VARIANT         145..146
FT                   /note="DV -> EL (in PFRD)"
SQ   SEQUENCE   595 AA;  69742 MW;  488CBD79C2901879 CRC64;
     MAAVDDATGL EAARKQKIHN LKLKTACLEN EELVQELHVS DWSETQRQKL RGAHLKAEEL
     VAAVDVGTKW NLTEVYDLAK LMRVCGLEMS QRELYRPEDK AQFMDIIAMK KVLQDLRQNR
     NKTRVVSFTQ MIDNAIAKVE KVEEDVRRSQ LDATQLAQVP TQTLKQVEDI MNVTQIQNAL
     ASTDDQIKTQ LAHVEKTNEI QNVAMHDGEM QVAEEQMWTK VQLQERLIDL IQDKFRLISK
     CEEENQAFSK IHEVQKQANQ ETSQMKDAKR RLKQRCETDL KHIHDAIQKA DLEDAEATKR
     HAANKEKSDR YIRENEDRQE ETWNKIQDLE RQLQKLGTER FDEVKRRIEE IDREEKRRVE
     YSQFLEVASQ HKKLLELTVY NCDLAIRCTG LVEELVSEGC AAVKARHDKT SQDLAALRLD
     VHKEHLEYFR MLYLTLGSLI YKKEKRMEEI DRNIRTTHIQ LEFCVETFDP NAKKHADMKK
     ELYRLRQGVE EELAMLKEKQ AKALEEFKES EEVSGRCWHR VQPPCDENNE EVLTRRSKMV
     EYRSHLTKQE EVKIAAEREE IKRALTAQLW CRWRAGPHRK QHCTHASNSV AAIIM