ID   PFS2_ASHGO              Reviewed;         449 AA.
AC   Q75AV4;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Polyadenylation factor subunit 2;
GN   Name=PSF2; OrderedLocusNames=ADL184W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required for 3'-end cleavage and polyadenylation of pre-
CC       mRNAs. Also involved in chromosome segregation where it has a role in
CC       chromosome attachment to the mitotic spindle (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; AE016817; AAS51736.1; -; Genomic_DNA.
DR   RefSeq; NP_983912.1; NM_209265.1.
DR   AlphaFoldDB; Q75AV4; -.
DR   SMR; Q75AV4; -.
DR   STRING; 33169.AAS51736; -.
DR   EnsemblFungi; AAS51736; AAS51736; AGOS_ADL184W.
DR   GeneID; 4620054; -.
DR   KEGG; ago:AGOS_ADL184W; -.
DR   eggNOG; KOG0284; Eukaryota.
DR   HOGENOM; CLU_000288_77_0_1; -.
DR   InParanoid; Q75AV4; -.
DR   OMA; HHWDVKS; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR   GO; GO:0098789; P:pre-mRNA cleavage required for polyadenylation; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR045245; Pfs2-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR22836; PTHR22836; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; mRNA processing; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..449
FT                   /note="Polyadenylation factor subunit 2"
FT                   /id="PRO_0000238495"
FT   REPEAT          77..116
FT                   /note="WD 1"
FT   REPEAT          119..158
FT                   /note="WD 2"
FT   REPEAT          161..200
FT                   /note="WD 3"
FT   REPEAT          203..242
FT                   /note="WD 4"
FT   REPEAT          245..285
FT                   /note="WD 5"
FT   REPEAT          288..328
FT                   /note="WD 6"
FT   REPEAT          337..376
FT                   /note="WD 7"
FT   REGION          411..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..432
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   449 AA;  50628 MW;  EA2A68DAAC54BB66 CRC64;
     MNSANDGSVK KYVSQRRTVD MSSPYDRLYF YKKHAIPLRT IQPESTYTAD IMPPDAYRDH
     RRVLNIPTKF THLSSNKVKH VIPAITWTPE GRRLVVATYS GEFSLWNGSS FNFESIMQAH
     DSAVTVMQYS HAGDWLISGD ADGTIKIWQP NFNMVKVLDR AHTECMRDIS FSYSDQKFVT
     CSDDNVLKIW NFSNGQQERV LSGHHWDVKS CDWHPKMGLI VSGSKDNLIK LWDPRTGRNV
     STILGLKHTV IKTKFQPTQG NLLAVVSKDK SIKIYDMRQH MRELQTIRDD MDYMSLSWHP
     INETIFSVGC YNGAIKHFDL LHDNSNSTPA CHTIPYAHEK SVTSLAYSPV GHILASAAKD
     RTIRFWARSR PVDPNAFDDP TYNNKKVNAW YFGINNNINA VRPKTEHGIA LPPANETNLG
     TPQPSILGSE SIAANNGNVP ASGLPGLSF