ID   PFS2_ASPOR              Reviewed;         610 AA.
AC   Q2TZG4;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Polyadenylation factor subunit 2;
GN   Name=pfs2; ORFNames=AO090011000862;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Required for 3'-end cleavage and polyadenylation of pre-
CC       mRNAs. Also involved in chromosome segregation where it has a role in
CC       chromosome attachment to the mitotic spindle (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; AP007171; BAE65301.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2TZG4; -.
DR   SMR; Q2TZG4; -.
DR   STRING; 510516.Q2TZG4; -.
DR   EnsemblFungi; BAE65301; BAE65301; AO090011000862.
DR   VEuPathDB; FungiDB:AO090011000862; -.
DR   HOGENOM; CLU_000288_77_1_1; -.
DR   OMA; DGSIHHY; -.
DR   Proteomes; UP000006564; Chromosome 7.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:EnsemblFungi.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0031124; P:mRNA 3'-end processing; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR045245; Pfs2-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR22836; PTHR22836; 1.
DR   Pfam; PF00400; WD40; 6.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; mRNA processing; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..610
FT                   /note="Polyadenylation factor subunit 2"
FT                   /id="PRO_0000238497"
FT   REPEAT          96..135
FT                   /note="WD 1"
FT   REPEAT          142..182
FT                   /note="WD 2"
FT   REPEAT          184..223
FT                   /note="WD 3"
FT   REPEAT          226..265
FT                   /note="WD 4"
FT   REPEAT          268..308
FT                   /note="WD 5"
FT   REPEAT          311..351
FT                   /note="WD 6"
FT   REPEAT          381..420
FT                   /note="WD 7"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          480..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          574..610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..610
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   610 AA;  67397 MW;  14BAE4922B6159DF CRC64;
     MAFYDDSGAD SQPFGRPQKP YEGGIVGPRR PRLVTDYGSS LVQWMRTRRP RYKGGHRMET
     ERPSASYIVD MLPPLARIHS PVDTIPVRHL HQSIGKSKKP ITVVRWTPEG RRLLTGGHTG
     EFMLWNGTAF NFETVMDAHY DQLQAGVTSL AWSHSHDWLI SGGQKGDIKY WRPNFNNVET
     IDDAHHDAVR DLAWSPSDTK FLSASDDTTL KIFDFTSRTA DTVLTGHNWD VKSCDWHPTK
     GLLVSGSKDH QVKFWDPRTA RCLTTLHSHK NTVTATRFSR VNQNLLATSS RDQTARVFDL
     RMMRDICILR GHEKPVSSLT WHPIHSSLIS TGSEDGSLYH YLLDEPNVPS GQIPTIAPYD
     SPDPANTPAQ VIYPAHRVQY AHSATIWSLD WHPLGHILAS GSKDNFTRFW SRARPGETSY
     MKDRFHIGEE AAEAQGTWSR GFGRRQMREE EEQELQDEAE SLVDQRKPTG SVLPGIQIAP
     PGGTPHNDGL GSQLLPGIGA PQPPPAPSAG IPSSMPQMDP NRLAALLSTQ GAPQPNSIPP
     NTGFPGFPML PALSGTPPAN VDLAELQKQL MSQGIPLPQN FAPQHFSPLP GTGGLPGLQG
     SNTPDNPYGR