ID   PFS2_CANAL              Reviewed;         543 AA.
AC   Q59WJ4; A0A1D8PF28;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Polyadenylation factor subunit 2;
GN   Name=PFS2; OrderedLocusNames=CAALFM_C111090CA;
GN   ORFNames=CaO19.2307, CaO19.9843;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Required for 3'-end cleavage and polyadenylation of pre-
CC       mRNAs. Also involved in chromosome segregation where it has a role in
CC       chromosome attachment to the mitotic spindle (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CP017623; AOW26735.1; -; Genomic_DNA.
DR   RefSeq; XP_713912.2; XM_708819.2.
DR   AlphaFoldDB; Q59WJ4; -.
DR   SMR; Q59WJ4; -.
DR   STRING; 237561.Q59WJ4; -.
DR   GeneID; 3644415; -.
DR   KEGG; cal:CAALFM_C111090CA; -.
DR   CGD; CAL0000196733; orf19.9843.
DR   VEuPathDB; FungiDB:C1_11090C_A; -.
DR   eggNOG; KOG0284; Eukaryota.
DR   HOGENOM; CLU_000288_77_1_1; -.
DR   InParanoid; Q59WJ4; -.
DR   OrthoDB; 604979at2759; -.
DR   PRO; PR:Q59WJ4; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR045245; Pfs2-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR22836; PTHR22836; 1.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; mRNA processing; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..543
FT                   /note="Polyadenylation factor subunit 2"
FT                   /id="PRO_0000238498"
FT   REPEAT          133..172
FT                   /note="WD 1"
FT   REPEAT          175..215
FT                   /note="WD 2"
FT   REPEAT          216..255
FT                   /note="WD 3"
FT   REPEAT          258..297
FT                   /note="WD 4"
FT   REPEAT          300..341
FT                   /note="WD 5"
FT   REPEAT          344..384
FT                   /note="WD 6"
FT   REPEAT          414..453
FT                   /note="WD 7"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          486..543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        518..534
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   543 AA;  60961 MW;  DABD5DBACC17916F CRC64;
     MYRSHNNNNN YHSRNDGSNG RINKPRDPKS QDKYVAYQQN IEQQLASQEK KQAYRRITDH
     GNNMGRWYIE KSLGLTNRSQ QAIGTIRPES SYLIDLLPSL AYSSSFNLNR RNNKNNLAVL
     DLQTKFVHLS SNKVKHTINT VKWTPEGRRL LVASHSGEFT LWNGMTFNFE TIMQAHESPI
     LTMKYSNHDE WLLSGDQNGT VKYWQPNFNN VNNISAHANG VRDIAFSPND SKFLTCGDDS
     AIKIWNFNNG KEERTLSGHH WEVKSADWHP NLGLIVSGSK DNLVKLWDPR SANCVSTLHG
     FKHTVNKTRF QPNGTARLLA SVSRDRSCRI FDLRTMKDML VIRDSETDLS CVAWHPIHAS
     MVTTAAYNGS ISNFLLDSYI PDSNESVPKR SNNNSNLSTN TNNTIDAVQK IPYAHEKAIH
     AVEYHPLGHL LCTAGSDKTA RFWSRARPND PMAWKDAVYT DCKAGAWYYS VNNNVNAVME
     DPNAVKNEDD EIANNDDPLS NSGRRRGVGA SASGGATGSV PGLRSRNETP NNGSYAIPGL
     RGF