ID   PFS2_CANGA              Reviewed;         455 AA.
AC   Q6FJS0;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Polyadenylation factor subunit 2;
GN   Name=PFS2; OrderedLocusNames=CAGL0M04081g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for 3'-end cleavage and polyadenylation of pre-
CC       mRNAs. Also involved in chromosome segregation where it has a role in
CC       chromosome attachment to the mitotic spindle (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR380959; CAG62500.1; -; Genomic_DNA.
DR   RefSeq; XP_449524.1; XM_449524.1.
DR   AlphaFoldDB; Q6FJS0; -.
DR   SMR; Q6FJS0; -.
DR   STRING; 5478.XP_449524.1; -.
DR   PRIDE; Q6FJS0; -.
DR   EnsemblFungi; CAG62500; CAG62500; CAGL0M04081g.
DR   GeneID; 2891533; -.
DR   KEGG; cgr:CAGL0M04081g; -.
DR   CGD; CAL0136357; CAGL0M04081g.
DR   VEuPathDB; FungiDB:CAGL0M04081g; -.
DR   eggNOG; KOG0284; Eukaryota.
DR   HOGENOM; CLU_000288_77_0_1; -.
DR   InParanoid; Q6FJS0; -.
DR   OMA; HHWDVKS; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:EnsemblFungi.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IEA:EnsemblFungi.
DR   GO; GO:0098789; P:pre-mRNA cleavage required for polyadenylation; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR045245; Pfs2-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR22836; PTHR22836; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; mRNA processing; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..455
FT                   /note="Polyadenylation factor subunit 2"
FT                   /id="PRO_0000238499"
FT   REPEAT          80..119
FT                   /note="WD 1"
FT   REPEAT          122..162
FT                   /note="WD 2"
FT   REPEAT          164..203
FT                   /note="WD 3"
FT   REPEAT          206..245
FT                   /note="WD 4"
FT   REPEAT          248..288
FT                   /note="WD 5"
FT   REPEAT          291..331
FT                   /note="WD 6"
FT   REPEAT          337..376
FT                   /note="WD 7"
FT   REGION          406..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          430..455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   455 AA;  51570 MW;  58AE916549E3C8E2 CRC64;
     MDQSAAVEGV PQKKYLTLRR SVDVSSSYNR LYYLKKHGLS LPPIEPETSF TANIMPPDAY
     KRNDRIVNLP TKFTHLSSNK VKHVIPAIQW SPEGRRLIVA TFSGEFSLWN GSSFTFETIM
     QAHDTSVTTM KYSHAGDWMI SGDADGTIKI WQPNFNMVKE LDRIHTEGIR DVAFSNNDSK
     FVTCSDDNIL KIWNFSNGQQ ERVLSGHHWD VRSCDWHPEL GLIVSGSKDN LVKLWDPRSG
     QCVSTLLKFK HTVLKTRFQP TKGNLLAAIS KDKSCRVFDL RASMNELMCV RDEVDFMELE
     WSTINESMFT VGCYDGSLKH FDLGQDTEKP IHIIPFAHEK CISAIAYNPV GHILATAAKD
     RTIRFWTRAR PVDPNAFDDP TYNNKKMTGW FFGINNDINA VREKSEYGAA PPPASTAFPQ
     QTQYNNNISR VPEIKEPTPT TDKEQRTSIL PGLSI