ID   PFS2_DEBHA              Reviewed;         504 AA.
AC   Q6BVZ3;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Polyadenylation factor subunit 2;
GN   Name=PFS2; OrderedLocusNames=DEHA2B15554g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for 3'-end cleavage and polyadenylation of pre-
CC       mRNAs. Also involved in chromosome segregation where it has a role in
CC       chromosome attachment to the mitotic spindle (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR382134; CAG85640.2; -; Genomic_DNA.
DR   RefSeq; XP_457626.2; XM_457626.1.
DR   AlphaFoldDB; Q6BVZ3; -.
DR   SMR; Q6BVZ3; -.
DR   STRING; 4959.XP_457626.2; -.
DR   EnsemblFungi; CAG85640; CAG85640; DEHA2B15554g.
DR   GeneID; 2913601; -.
DR   KEGG; dha:DEHA2B15554g; -.
DR   eggNOG; KOG0284; Eukaryota.
DR   HOGENOM; CLU_000288_77_1_1; -.
DR   InParanoid; Q6BVZ3; -.
DR   OMA; HHWDVKS; -.
DR   OrthoDB; 604979at2759; -.
DR   Proteomes; UP000000599; Chromosome B.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0031124; P:mRNA 3'-end processing; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR045245; Pfs2-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR22836; PTHR22836; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; mRNA processing; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..504
FT                   /note="Polyadenylation factor subunit 2"
FT                   /id="PRO_0000238501"
FT   REPEAT          120..159
FT                   /note="WD 1"
FT   REPEAT          162..201
FT                   /note="WD 2"
FT   REPEAT          203..242
FT                   /note="WD 3"
FT   REPEAT          245..284
FT                   /note="WD 4"
FT   REPEAT          287..328
FT                   /note="WD 5"
FT   REPEAT          331..373
FT                   /note="WD 6"
FT   REPEAT          393..432
FT                   /note="WD 7"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          463..504
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        463..497
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   504 AA;  56696 MW;  97315AB262AAC935 CRC64;
     MFNNNSNNGN SNGNRGYNNN NRNNERSQGY NQNIEQQLAS QEKKTAYRRT VDHGNNMGRW
     YINRSLGIDD QPIGKIRPES SYLIDLLPSP AYASNSVREN KNNMSIMDIQ TKFVHLSSNK
     AKHSINTVKW TPEGRRLLVA SHSGEFTVWN GMTFNFETIM QAHDSAILSL KYSHNDEWLL
     SGDQSGVIKY WQTNFNNVNI INGHSDGIRD IAFSPNDSKF LTCSDDSTMK IWNFNNGQEE
     RSLVGHHWDV KSADWHPNLG LIVSGSKDNL IKLWDPRASS CVSTLHGFKH TITKTKFQPT
     GTKRLLASVS RDKSCRIFDL RTMKDILVIR DHETDLSCVE WHPVHPSMIT TAAYDGSMNH
     YIMDSYISDN NIKNDSNNNS TSPIEASHKI PYAHEKAIHA LEYHPLGHLL CSAGADRSAR
     FWSRARPNDP MSFQDALYTN DKVGAWYYGV NNNINAVIEP STASVNKDDP SSAQAINLPG
     LNNLPNGNES TTNGWGNIPG LRGH