PFS2_GIBZE
ID PFS2_GIBZE Reviewed; 612 AA.
AC Q4I7X1; A0A0E0SF71; V6RDX2;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Polyadenylation factor subunit 2;
GN Name=PFS2; ORFNames=FGRRES_06687, FGSG_06687;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Required for 3'-end cleavage and polyadenylation of pre-
CC mRNAs. Also involved in chromosome segregation where it has a role in
CC chromosome attachment to the mitotic spindle (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; DS231666; ESU12813.1; -; Genomic_DNA.
DR EMBL; HG970335; CEF85084.1; -; Genomic_DNA.
DR RefSeq; XP_011326320.1; XM_011328018.1.
DR AlphaFoldDB; Q4I7X1; -.
DR SMR; Q4I7X1; -.
DR STRING; 5518.FGSG_06687P0; -.
DR EnsemblFungi; ESU12813; ESU12813; FGSG_06687.
DR GeneID; 23553809; -.
DR KEGG; fgr:FGSG_06687; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G22917; -.
DR eggNOG; KOG0284; Eukaryota.
DR HOGENOM; CLU_000288_77_1_1; -.
DR InParanoid; Q4I7X1; -.
DR Proteomes; UP000070720; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR045245; Pfs2-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR22836; PTHR22836; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromosome partition; mRNA processing; Nucleus; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..612
FT /note="Polyadenylation factor subunit 2"
FT /id="PRO_0000238503"
FT REPEAT 93..132
FT /note="WD 1"
FT REPEAT 135..175
FT /note="WD 2"
FT REPEAT 177..215
FT /note="WD 3"
FT REPEAT 218..257
FT /note="WD 4"
FT REPEAT 260..300
FT /note="WD 5"
FT REPEAT 303..345
FT /note="WD 6"
FT REPEAT 373..412
FT /note="WD 7"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..576
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 66452 MW; AEACB25BA6DE72CE CRC64;
MAYEPRGDHG GGGGGQGQDG AFVKVRGRRP VTDYGATITH WQHDRAPGYK GGYTGEAERP
SASYIVDMLP PAARVTKAAD SIPIKHLHSS LNKIKHPINV VRWTPEGRRL LTASTSGEFT
LWNGTGFNFE TIMQAHDSAI RALEYSHSDD WLISADHDGA VKYWQPNFNN VQSINAHTDP
IRDLAFSPSD SKFVTASDDS TLKIFDFALG QMESKLEGHG WDAKSVDWHP TKGLLVSGSK
DHLVKLWDPR TSRCLTTLHG HKSTITKVLF EKVRGACLAT SARDQTARVF DLRMMRDICL
LKGHEKDIST LTWHPVHPNL LSTGGMDGSL FHYLLDSPNP PPGQSFTVAP YDSPDPTTVP
AQSVWPTHKV PYAHDYAIWS LDWHPLGHIL ASGSNDRITR FWSRARPGDA EVFQDRYHIG
EAAAEAQGTW DRRGGRRQRQ EEEQQEMEDE MDALVDQDAP KAGVPGLPGI PGLPLGGLPG
LGSAVPPPPI PGVGAGGPPP PLPFPLPGLN GSLPPPPLPG LDPNNPPDPA QLLELMKKAG
VPLPPPGALP PGLLPPGGIP PPPGGFGMPI PPPPMSALEA EKAENVRRRA PLPSQEDSLR
HEQRQGKYTR AR
