ID   PFS2_NEUCR              Reviewed;         660 AA.
AC   Q7RY68; U9W884;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Polyadenylation factor subunit 2;
GN   Name=paa-1; Synonyms=pfs2; ORFNames=NCU00037;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Required for 3'-end cleavage and polyadenylation of pre-
CC       mRNAs. Also involved in chromosome segregation where it has a role in
CC       chromosome attachment to the mitotic spindle (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CM002238; ESA43240.1; -; Genomic_DNA.
DR   RefSeq; XP_011393733.1; XM_011395431.1.
DR   AlphaFoldDB; Q7RY68; -.
DR   SMR; Q7RY68; -.
DR   STRING; 5141.EFNCRP00000000117; -.
DR   EnsemblFungi; ESA43240; ESA43240; NCU00037.
DR   GeneID; 3873162; -.
DR   KEGG; ncr:NCU00037; -.
DR   VEuPathDB; FungiDB:NCU00037; -.
DR   HOGENOM; CLU_000288_77_1_1; -.
DR   InParanoid; Q7RY68; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR045245; Pfs2-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR22836; PTHR22836; 1.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; mRNA processing; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..660
FT                   /note="Polyadenylation factor subunit 2"
FT                   /id="PRO_0000238505"
FT   REPEAT          94..133
FT                   /note="WD 1"
FT   REPEAT          136..176
FT                   /note="WD 2"
FT   REPEAT          177..216
FT                   /note="WD 3"
FT   REPEAT          219..258
FT                   /note="WD 4"
FT   REPEAT          261..301
FT                   /note="WD 5"
FT   REPEAT          304..344
FT                   /note="WD 6"
FT   REPEAT          376..415
FT                   /note="WD 7"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          562..660
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        564..614
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        645..660
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  71280 MW;  07477E9D2C3E0ED1 CRC64;
     MSYEPRGDHD KGYGGGGGHD GLPPRNRGRR PVTDYGASVV HYMRHRQPRY RGSYAGEVER
     PSPSYIVDML PPYARVTNPA DSVPSRHLHS SLNKIKHPIN VVRWTPEGRR LLTASSSGEF
     TLWNGTGFNF ETIMQAHDSA IRALVYSHSD DWLVSADHDG IIKYWQPNFN NVESIRGHTD
     PIRDLAFSPN DTKFVTASDD QTLKVFDFAG GSTDMTLTGH GWDAKSCDWH PSRGLIVSGS
     KDHLVKLWDP RTGRCLTTLH GHKNTITKTL FERVQGNCLA TSARDQTARV FDLRMMRDIA
     LLRGHEKDIS TLTWHPVHSN LLSTGGSDGS LFHYLLDEPN TAPDGSVMPI PAVYDTADPS
     SAPAQPIYPA HKIPYAHDFA IWSLDWHPLG HILASGSNDR ITRFWSRARP GEAPESFNDR
     YHIGEAAAEA QGTWDRRGGR HMRQVEEEQE LEDEMDGLVD QKMPIKGQPG VGGGGMMPGL
     SFPSIPGLPL QQVPSSGPGG SGFIPPPPII PGVGGATGVP PPLPFPIPGM PGLPAGVVPP
     PLPGLDLKNP PDFSALAEMM KKAGYQPPPP PGSAGAPMPP PGILPPGLIP PPGAAGFPMP
     PPGFAPPPLI PGAGGPPGGA THPDGGNDQY DSSGRRRAPL PSQEESLRME QSKGNYTRVR