ID   PFS2_YARLI              Reviewed;         532 AA.
AC   Q6CGP9;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Polyadenylation factor subunit 2;
GN   Name=PFS2; OrderedLocusNames=YALI0A17424g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for 3'-end cleavage and polyadenylation of pre-
CC       mRNAs. Also involved in chromosome segregation where it has a role in
CC       chromosome attachment to the mitotic spindle (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR382127; CAG84095.1; -; Genomic_DNA.
DR   RefSeq; XP_500163.1; XM_500163.1.
DR   AlphaFoldDB; Q6CGP9; -.
DR   SMR; Q6CGP9; -.
DR   STRING; 4952.CAG84095; -.
DR   EnsemblFungi; CAG84095; CAG84095; YALI0_A17424g.
DR   GeneID; 2905837; -.
DR   KEGG; yli:YALI0A17424g; -.
DR   VEuPathDB; FungiDB:YALI0_A17424g; -.
DR   HOGENOM; CLU_000288_77_1_1; -.
DR   InParanoid; Q6CGP9; -.
DR   OMA; HHWDVKS; -.
DR   Proteomes; UP000001300; Chromosome A.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR045245; Pfs2-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR22836; PTHR22836; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; mRNA processing; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..532
FT                   /note="Polyadenylation factor subunit 2"
FT                   /id="PRO_0000238506"
FT   REPEAT          143..182
FT                   /note="WD 1"
FT   REPEAT          185..224
FT                   /note="WD 2"
FT   REPEAT          227..266
FT                   /note="WD 3"
FT   REPEAT          270..309
FT                   /note="WD 4"
FT   REPEAT          312..353
FT                   /note="WD 5"
FT   REPEAT          376..416
FT                   /note="WD 6"
FT   REPEAT          432..471
FT                   /note="WD 7"
FT   REGION          50..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          513..532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..72
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   532 AA;  58961 MW;  B86FC388ED8302F8 CRC64;
     MSSDSGPLHR RTIPISVHIF SGFFYAPFYA PQLTQFIVTI TMYSTYQRPA GYQPRQQPQG
     EEDRRPAHRR TVDHGSAFGK WHLDRLSGRT IQPANMRSEQ SYIVDLLPPS AYTNINGSLR
     STNPHITSVA ATPAKFIQVA LNKVRHPVYS ATWTPDGRRL LTGSMSGEFT LWNGMTFNFE
     SIMQAHESGV RSLKYSHSGE WLLSGDHEGN VKFWQPSLNC VNVIDKAHRE SIRELAFAPS
     DHKFVTGSDD GLLKIWDFHE SSNAESVLKG HGWDVKSVDW HSELGLIVSG SKDNLIKLWD
     PRSAKNVNTF HGFKNTVMKT TFQPTGTKRL LAAGCRDRTC RILDLRMLNS GSSEAGPTAG
     TDMPTRGDRS MAVLRGHDSD VFSLTWHPTH ANVVTSGTKT GSIYTFNVDT TPAGGAYGPD
     SGILPVNTIP SAHDYCVSTL DYHPEGHVLC SGGLDRMTRF WARPRPGDPT SFRDKYYEPK
     EEGVSVKTLP GVNNATSRAG MARVEHVSTQ HFNTAQPEVT DDEPVSIPGF AR