ID   PG08_MYCTU              Reviewed;         175 AA.
AC   I6Y8K5;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   19-FEB-2014, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=PE-PGRS family protein PE_PGRS8 {ECO:0000305};
GN   Name=PE_PGRS8 {ECO:0000312|EMBL:CCP43487.1};
GN   OrderedLocusNames=Rv0742 {ECO:0000312|EMBL:CCP43487.1};
GN   ORFNames=LH57_04020 {ECO:0000312|EMBL:AIR13472.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=27483162; DOI=10.1021/acs.biochem.6b00289;
RA   Yeruva V.C., Kulkarni A., Khandelwal R., Sharma Y., Raghunand T.R.;
RT   "The PE_PGRS proteins of Mycobacterium tuberculosis are Ca(2+) binding
RT   mediators of host-pathogen interaction.";
RL   Biochemistry 55:4675-4687(2016).
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC       {ECO:0000269|PubMed:27483162}. Cell surface
CC       {ECO:0000269|PubMed:27483162}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PE family. PGRS subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP43487.1; -; Genomic_DNA.
DR   EMBL; CP009480; AIR13472.1; -; Genomic_DNA.
DR   RefSeq; WP_003901009.1; NZ_NVQJ01000007.1.
DR   RefSeq; YP_177749.1; NC_000962.3.
DR   AlphaFoldDB; I6Y8K5; -.
DR   SMR; I6Y8K5; -.
DR   PaxDb; I6Y8K5; -.
DR   GeneID; 45424707; -.
DR   GeneID; 888645; -.
DR   KEGG; mtu:Rv0742; -.
DR   PATRIC; fig|83332.111.peg.821; -.
DR   TubercuList; Rv0742; -.
DR   eggNOG; COG0657; Bacteria.
DR   HOGENOM; CLU_000167_16_0_11; -.
DR   OMA; MMIPRSA; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   InterPro; IPR000084; PE-PGRS_N.
DR   Pfam; PF00934; PE; 1.
PE   3: Inferred from homology;
KW   Cell wall; Reference proteome; Secreted.
FT   CHAIN           1..175
FT                   /note="PE-PGRS family protein PE_PGRS8"
FT                   /id="PRO_5008166656"
FT   DOMAIN          1..93
FT                   /note="PE"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   175 AA;  15545 MW;  C62849BE8B51A4E9 CRC64;
     MSFVIAAPEA IAAAATDLAS IGSTIGAANA AAAANTTAVL AAGADQVSVA IAAAFGAHGQ
     AYQALSAQAA TFHIQFVQAL TAGAGSYAAA EAASAASITS PLLDAINAPF LAALGRPLIG
     NGADGAPGTG AAGGAGGLLF GNGGAGGSGA PGGAGGLLFG NGGAGGPGAS GGALG