PG12B_HUMAN
ID PG12B_HUMAN Reviewed; 195 AA.
AC Q9BX93; B7ZL23; Q52LB2; Q96Q99;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2002, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Group XIIB secretory phospholipase A2-like protein;
DE AltName: Full=Group XIII secretory phospholipase A2-like protein;
DE Short=GXIII sPLA2-like;
DE AltName: Full=sPLA2-GXIIB;
DE Short=GXIIB;
DE Flags: Precursor;
GN Name=PLA2G12B; Synonyms=PLA2G13; ORFNames=FKSG71;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Takahashi K.;
RT "Cloning of human group XIII secreted phospholipase A2.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Wang Y.-G., Gong L.;
RT "Cloning and characterization of FKSG71, a novel gene encoding group XIII
RT secreted phospholipase A2.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), LACK OF ENZYME ACTIVITY, AND TISSUE
RP SPECIFICITY.
RX PubMed=14516201; DOI=10.1021/bi0349930;
RA Rouault M., Bollinger J.G., Lazdunski M., Gelb M.H., Lambeau G.;
RT "Novel mammalian group XII secreted phospholipase A2 lacking enzymatic
RT activity.";
RL Biochemistry 42:11494-11503(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 20-34.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- FUNCTION: Not known; does not seem to have catalytic activity.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BX93-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BX93-2; Sequence=VSP_054398;
CC -!- TISSUE SPECIFICITY: Strong expression in liver, small intestine and
CC kidney. {ECO:0000269|PubMed:14516201}.
CC -!- SIMILARITY: Belongs to the phospholipase A2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF349540; AAK30168.1; -; mRNA.
DR EMBL; AF339053; AAL09472.1; -; mRNA.
DR EMBL; AY358032; AAQ92918.1; -; mRNA.
DR EMBL; CH471083; EAW54466.1; -; Genomic_DNA.
DR EMBL; BC093996; AAH93996.1; -; mRNA.
DR EMBL; BC111946; AAI11947.1; -; mRNA.
DR EMBL; BC143532; AAI43533.1; -; mRNA.
DR CCDS; CCDS7319.1; -. [Q9BX93-1]
DR RefSeq; NP_001305053.1; NM_001318124.1. [Q9BX93-2]
DR RefSeq; NP_115951.2; NM_032562.4. [Q9BX93-1]
DR AlphaFoldDB; Q9BX93; -.
DR BioGRID; 124170; 4.
DR IntAct; Q9BX93; 1.
DR STRING; 9606.ENSP00000362123; -.
DR BindingDB; Q9BX93; -.
DR ChEMBL; CHEMBL4524005; -.
DR BioMuta; PLA2G12B; -.
DR DMDM; 20178010; -.
DR jPOST; Q9BX93; -.
DR MassIVE; Q9BX93; -.
DR MaxQB; Q9BX93; -.
DR PaxDb; Q9BX93; -.
DR PeptideAtlas; Q9BX93; -.
DR PRIDE; Q9BX93; -.
DR ProteomicsDB; 79387; -. [Q9BX93-1]
DR Antibodypedia; 45352; 41 antibodies from 15 providers.
DR DNASU; 84647; -.
DR Ensembl; ENST00000373032.4; ENSP00000362123.3; ENSG00000138308.6. [Q9BX93-1]
DR GeneID; 84647; -.
DR KEGG; hsa:84647; -.
DR MANE-Select; ENST00000373032.4; ENSP00000362123.3; NM_032562.5; NP_115951.2.
DR UCSC; uc001jtf.2; human. [Q9BX93-1]
DR CTD; 84647; -.
DR DisGeNET; 84647; -.
DR GeneCards; PLA2G12B; -.
DR HGNC; HGNC:18555; PLA2G12B.
DR HPA; ENSG00000138308; Tissue enhanced (intestine, kidney, liver).
DR MIM; 611653; gene.
DR neXtProt; NX_Q9BX93; -.
DR OpenTargets; ENSG00000138308; -.
DR PharmGKB; PA38573; -.
DR VEuPathDB; HostDB:ENSG00000138308; -.
DR eggNOG; ENOG502QQU1; Eukaryota.
DR GeneTree; ENSGT00390000008798; -.
DR HOGENOM; CLU_093969_1_1_1; -.
DR InParanoid; Q9BX93; -.
DR OMA; KNGICQY; -.
DR OrthoDB; 1299904at2759; -.
DR PhylomeDB; Q9BX93; -.
DR TreeFam; TF323302; -.
DR PathwayCommons; Q9BX93; -.
DR SignaLink; Q9BX93; -.
DR BioGRID-ORCS; 84647; 6 hits in 1066 CRISPR screens.
DR GenomeRNAi; 84647; -.
DR Pharos; Q9BX93; Tdark.
DR PRO; PR:Q9BX93; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q9BX93; protein.
DR Bgee; ENSG00000138308; Expressed in jejunal mucosa and 41 other tissues.
DR Genevisible; Q9BX93; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004623; F:phospholipase A2 activity; IEA:InterPro.
DR GO; GO:0050482; P:arachidonic acid secretion; IEA:InterPro.
DR GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central.
DR GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR GO; GO:0006644; P:phospholipid metabolic process; IEA:InterPro.
DR GO; GO:0070328; P:triglyceride homeostasis; IBA:GO_Central.
DR Gene3D; 1.20.90.10; -; 1.
DR InterPro; IPR010711; PLA2G12.
DR InterPro; IPR036444; PLipase_A2_dom_sf.
DR PANTHER; PTHR12824; PTHR12824; 1.
DR Pfam; PF06951; PLA2G12; 1.
DR SUPFAM; SSF48619; SSF48619; 1.
DR PROSITE; PS00014; ER_TARGET; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Calcium; Direct protein sequencing; Metal-binding;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 20..195
FT /note="Group XIIB secretory phospholipase A2-like protein"
FT /id="PRO_0000022772"
FT BINDING 89
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 91
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 93
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 116
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT VAR_SEQ 157
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_054398"
SQ SEQUENCE 195 AA; 21659 MW; C00C817F81D68A70 CRC64;
MKLASGFLVL WLSLGGGLAQ SDTSPDTEES YSDWGLRHLR GSFESVNSYF DSFLELLGGK
NGVCQYRCRY GKAPMPRPGY KPQEPNGCGS YFLGLKVPES MDLGIPAMTK CCNQLDVCYD
TCGANKYRCD AKFRWCLHSI CSDLKRSLGF VSKVEAACDS LVDTVFNTVW TLGCRPFMNS
QRAACICAEE EKEEL
