ID   PG12B_MOUSE             Reviewed;         195 AA.
AC   Q99P27;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Group XIIB secretory phospholipase A2-like protein;
DE   AltName: Full=Group XIII secretory phospholipase A2-like protein;
DE            Short=GXIII sPLA2-like;
DE   AltName: Full=sPLA2-GXIIB;
DE            Short=GXIIB;
DE   Flags: Precursor;
GN   Name=Pla2g12b; Synonyms=Pla2g13; ORFNames=Fksg71;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6 X DBA;
RA   Wang Y.-G., Gong L.;
RT   "Cloning and characterization of FKSG71, a novel gene encoding group XIII
RT   secreted phospholipase A2.";
RL   Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Not known; does not seem to have catalytic activity.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the phospholipase A2 family. {ECO:0000305}.
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DR   EMBL; AF339738; AAK01739.1; -; mRNA.
DR   CCDS; CCDS23864.1; -.
DR   AlphaFoldDB; Q99P27; -.
DR   IntAct; Q99P27; 1.
DR   STRING; 10090.ENSMUSP00000009790; -.
DR   jPOST; Q99P27; -.
DR   MaxQB; Q99P27; -.
DR   PaxDb; Q99P27; -.
DR   PRIDE; Q99P27; -.
DR   ProteomicsDB; 288177; -.
DR   MGI; MGI:1917086; Pla2g12b.
DR   eggNOG; ENOG502QQU1; Eukaryota.
DR   InParanoid; Q99P27; -.
DR   PhylomeDB; Q99P27; -.
DR   PRO; PR:Q99P27; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q99P27; protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004623; F:phospholipase A2 activity; IEA:InterPro.
DR   GO; GO:0050482; P:arachidonic acid secretion; IEA:InterPro.
DR   GO; GO:0042632; P:cholesterol homeostasis; IMP:MGI.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   GO; GO:0034374; P:low-density lipoprotein particle remodeling; IDA:MGI.
DR   GO; GO:0006644; P:phospholipid metabolic process; IEA:InterPro.
DR   GO; GO:0070328; P:triglyceride homeostasis; IMP:MGI.
DR   Gene3D; 1.20.90.10; -; 1.
DR   InterPro; IPR010711; PLA2G12.
DR   InterPro; IPR036444; PLipase_A2_dom_sf.
DR   PANTHER; PTHR12824; PTHR12824; 1.
DR   Pfam; PF06951; PLA2G12; 1.
DR   SUPFAM; SSF48619; SSF48619; 1.
DR   PROSITE; PS00014; ER_TARGET; 1.
PE   1: Evidence at protein level;
KW   Calcium; Metal-binding; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..195
FT                   /note="Group XIIB secretory phospholipase A2-like protein"
FT                   /id="PRO_0000022773"
FT   BINDING         89
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         91
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         93
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         116
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   195 AA;  21736 MW;  86F8E653BD08DA24 CRC64;
     MKLLCGFFLL WLGLVGNLAQ SDPSPKEEES YSDWGLRQLR GSFESVNSYV DSFMELLGGK
     NGVCQYRCRY GKAPMPRPGY KAQEPNGCSS YFLGIKVPGS MDLGIPAMTK CCNQLDVCYD
     TCGANKYRCD AKFRWCLHSI CSDLKRTLGF VSNVEAACDS LADTVFNTVW TLGCRPFMNS
     QRAACICAEE EKEEL