PG17_MYCTU
ID PG17_MYCTU Reviewed; 331 AA.
AC Q79FU2; I6WZY1; L0T899;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=PE-PGRS family protein PE_PGRS17 {ECO:0000305};
GN Name=PE_PGRS17 {ECO:0000312|EMBL:CCP43727.1};
GN OrderedLocusNames=Rv0978c {ECO:0000312|EMBL:CCP43727.1};
GN ORFNames=LH57_05330 {ECO:0000312|EMBL:AIR13712.1};
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA Monaco A., King S., Sohrabi A.;
RT "Phylogenetic analysis of Mycobacterial species using whole genome
RT sequences.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP INDUCTION.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=16586367; DOI=10.1086/502631;
RA Jain S.K., Paul-Satyaseela M., Lamichhane G., Kim K.S., Bishai W.R.;
RT "Mycobacterium tuberculosis invasion and traversal across an in vitro human
RT blood-brain barrier as a pathogenic mechanism for central nervous system
RT tuberculosis.";
RL J. Infect. Dis. 193:1287-1295(2006).
RN [4]
RP INVOLVEMENT IN B-CELL RESPONSE.
RX PubMed=17687113; DOI=10.1128/cvi.00181-07;
RA Narayana Y., Joshi B., Katoch V.M., Mishra K.C., Balaji K.N.;
RT "Differential B-cell responses are induced by Mycobacterium tuberculosis PE
RT antigens Rv1169c, Rv0978c, and Rv1818c.";
RL Clin. Vaccine Immunol. 14:1334-1341(2007).
RN [5]
RP FUNCTION, AND INTERACTION WITH TLR2.
RX PubMed=20176745; DOI=10.4049/jimmunol.0903299;
RA Bansal K., Elluru S.R., Narayana Y., Chaturvedi R., Patil S.A.,
RA Kaveri S.V., Bayry J., Balaji K.N.;
RT "PE_PGRS antigens of Mycobacterium tuberculosis induce maturation and
RT activation of human dendritic cells.";
RL J. Immunol. 184:3495-3504(2010).
RN [6]
RP EXPRESSION IN M.SMEGMATIS.
RX PubMed=23663047; DOI=10.1089/jir.2012.0083;
RA Chen T., Zhao Q., Li W., Xie J.;
RT "Mycobacterium tuberculosis PE_PGRS17 promotes the death of host cell and
RT cytokines secretion via Erk kinase accompanying with enhanced survival of
RT recombinant Mycobacterium smegmatis.";
RL J. Interferon Cytokine Res. 33:452-458(2013).
CC -!- FUNCTION: Induces maturation and activation of human dendritic cells
CC (DCs), via TLR2-dependent activation of ERK1/2, p38 MAPK, and NF-kappa-
CC B signaling pathways, and enhances the ability of DCs to stimulate
CC CD4(+) T cells. By activating DCs, could potentially contribute to the
CC initiation of innate immune responses during tuberculosis infection and
CC hence regulate the clinical course of tuberculosis.
CC {ECO:0000269|PubMed:20176745}.
CC -!- SUBUNIT: Interacts with human TLR2. {ECO:0000269|PubMed:20176745}.
CC -!- INDUCTION: Highly up-regulated during the early stages of invasion of
CC the human blood-brain barrier. {ECO:0000269|PubMed:16586367}.
CC -!- MISCELLANEOUS: Elicits a strong B-cell humoral response among different
CC clinical categories of both adult and child tuberculosis patients.
CC Could be used in the serodiagnosis of tuberculosis.
CC {ECO:0000269|PubMed:17687113}.
CC -!- MISCELLANEOUS: Expression of this gene in M.smegmatis leads to enhanced
CC survival within U937 human macrophages in vitro, with increased host
CC cell death and a marked higher secretion of tumor necrosis factor-
CC alpha. {ECO:0000269|PubMed:23663047}.
CC -!- SIMILARITY: Belongs to the mycobacterial PE family. PGRS subfamily.
CC {ECO:0000305}.
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DR EMBL; AL123456; CCP43727.1; -; Genomic_DNA.
DR EMBL; CP009480; AIR13712.1; -; Genomic_DNA.
DR RefSeq; WP_010886099.1; NC_000962.3.
DR RefSeq; YP_177774.1; NC_000962.3.
DR AlphaFoldDB; Q79FU2; -.
DR SMR; Q79FU2; -.
DR STRING; 83332.Rv0978c; -.
DR PaxDb; Q79FU2; -.
DR GeneID; 885077; -.
DR KEGG; mtu:Rv0978c; -.
DR PATRIC; fig|83332.111.peg.1085; -.
DR TubercuList; Rv0978c; -.
DR eggNOG; COG3391; Bacteria.
DR HOGENOM; CLU_000167_16_4_11; -.
DR OMA; QAYQMIS; -.
DR PhylomeDB; Q79FU2; -.
DR Proteomes; UP000001584; Chromosome.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR000084; PE-PGRS_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR011964; YVTN_b-propeller_repeat.
DR Pfam; PF01436; NHL; 1.
DR Pfam; PF00934; PE; 1.
DR TIGRFAMs; TIGR02276; beta_rpt_yvtn; 2.
DR PROSITE; PS51125; NHL; 3.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; Virulence.
FT CHAIN 1..331
FT /note="PE-PGRS family protein PE_PGRS17"
FT /id="PRO_5007710445"
FT DOMAIN 1..92
FT /note="PE"
FT /evidence="ECO:0000255"
FT REPEAT 217..247
FT /note="NHL 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00504"
FT REPEAT 260..290
FT /note="NHL 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00504"
FT REPEAT 305..331
FT /note="NHL 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00504"
SQ SEQUENCE 331 AA; 31019 MW; A093EC12F1691CA5 CRC64;
MSFVNVAPQL VSTAAADAAR IGSAINTANT AAAATTQVLA AAQDEVSTAI AALFGSHGQH
YQAISAQVAA YQQRFVLALS QAGSTYAVAE AASATPLQNV LDAINAPVQS LTGRPLIGDG
ANGIDGTGQA GGNGGWLWGN GGNGGSGAPG QAGGAGGAAG LIGNGGAGGT GGAVSLARAG
TAGGAGRGPV GGIGGAGGVG GAGGAAGAVT TITHASFNDP HGVAVNPGGN VYVTNFGSGT
VSVINPATNT VTGSPITIGN GPSGVAVSPV TGLVFVTNFD SNTVSVIDPT TNTVTGSPIT
VGTAPTGVAV NPVTGEVYVT NFAGDTVSVI S
