ID   PG26_MYCTU              Reviewed;         491 AA.
AC   Q79FP3; I6X191; L0T898;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=PE-PGRS family protein PE_PGRS26 {ECO:0000305};
GN   Name=PE_PGRS26 {ECO:0000312|EMBL:CCP44200.1};
GN   OrderedLocusNames=Rv1441c {ECO:0000312|EMBL:CCP44200.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION.
RX   PubMed=16672626; DOI=10.1128/jb.188.10.3721-3725.2006;
RA   Dheenadhayalan V., Delogu G., Sanguinetti M., Fadda G., Brennan M.J.;
RT   "Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes:
RT   evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo.";
RL   J. Bacteriol. 188:3721-3725(2006).
RN   [3]
RP   SUBCELLULAR LOCATION, AND EXPRESSION IN M.SMEGMATIS.
RX   PubMed=18957600; DOI=10.1099/mic.0.2008/019968-0;
RA   Singh P.P., Parra M., Cadieux N., Brennan M.J.;
RT   "A comparative study of host response to three Mycobacterium tuberculosis
RT   PE_PGRS proteins.";
RL   Microbiology 154:3469-3479(2008).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=H37Rv;
RX   PubMed=22050772; DOI=10.1111/j.1462-5822.2011.01721.x;
RA   Iantomasi R., Sali M., Cascioferro A., Palucci I., Zumbo A., Soldini S.,
RA   Rocca S., Greco E., Maulucci G., De Spirito M., Fraziano M., Fadda G.,
RA   Manganelli R., Delogu G.;
RT   "PE_PGRS30 is required for the full virulence of Mycobacterium
RT   tuberculosis.";
RL   Cell. Microbiol. 14:356-367(2012).
CC   -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:18957600}.
CC   -!- INDUCTION: Expression is down-regulated in macrophages and infected
CC       mice. {ECO:0000269|PubMed:16672626}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutant is partially attenuated during
CC       murine tuberculosis, but not during the chronic steps of infection. On
CC       day 28 post infection, shows a slight reduction of the bacterial
CC       burden, but on day 70, bacterial counts of the mutant are similar to
CC       the wild-type strain. {ECO:0000269|PubMed:22050772}.
CC   -!- MISCELLANEOUS: Expression of this gene in M.smegmatis leads to low
CC       levels of NO and IL-12, increased level of IL-10 and better survival of
CC       recombinant strains in macrophages. {ECO:0000269|PubMed:18957600}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PE family. PGRS subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP44200.1; -; Genomic_DNA.
DR   RefSeq; WP_010886116.1; NZ_KK339370.1.
DR   RefSeq; YP_177811.1; NC_000962.3.
DR   AlphaFoldDB; Q79FP3; -.
DR   STRING; 83332.Rv1441c; -.
DR   PaxDb; Q79FP3; -.
DR   GeneID; 886626; -.
DR   KEGG; mtu:Rv1441c; -.
DR   PATRIC; fig|83332.111.peg.1602; -.
DR   TubercuList; Rv1441c; -.
DR   eggNOG; COG0657; Bacteria.
DR   OMA; MGFADKI; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000084; PE-PGRS_N.
DR   Pfam; PF00934; PE; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..491
FT                   /note="PE-PGRS family protein PE_PGRS26"
FT                   /id="PRO_5004286886"
FT   DOMAIN          1..93
FT                   /note="PE"
FT                   /evidence="ECO:0000255"
FT   REGION          207..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   491 AA;  40810 MW;  0421AFF3F32DEE11 CRC64;
     MSNVMVVPGM LSAAAADVAS IGAALSAANG AAAPTTAGVL AAGADEVSAA IASLFSGYAR
     DYQALSAQMA RFHQQFVQAL TASVGSYAAA EAANASPLQA LEQQVLAAIN APTQTLLGRP
     LIGNGADGLP GQNGGAGGLL WGNGGNGGAG DAAHPNGGNG GDAGMFGNGG AGGAGYSPAA
     GTGAAGGAGG AGGAGGWLSG NGGAGGNGGT GASGADGGGG LPPVPASPGG NGGGGDAGGA
     AGMFGTGGAG GTGGDGGAGG AGDSPNSGAN GARGGDGGNG AAGGAGGRLF GNGGAGGNGG
     TAGQGGDGGT ALGAGGIGGD GGTGGAGGTG GTAGIGGSSA GAGGAGGDGG AGGTGGGSSM
     IGGKGGTGGN GGVGGTGGAS ALTIGNGSSA GAGGAGGAGG TGGTGGYIES LDGKGQAGNG
     GNGGNGAAGG AGGGGTGAGG NGGAGGNGGD GGPSQGGGNP GFGGDGGTGG PGGVGVPDGI
     GGANGAQGKH G