PG2_PIG
ID PG2_PIG Reviewed; 147 AA.
AC P32195;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Protegrin-2;
DE Short=PG-2;
DE Flags: Precursor;
GN Name=NPG2;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Bone marrow;
RX PubMed=8250892; DOI=10.1006/bbrc.1993.2403;
RA Storici P., Zanetti M.;
RT "A novel cDNA sequence encoding a pig leukocyte antimicrobial peptide with
RT a cathelin-like pro-sequence.";
RL Biochem. Biophys. Res. Commun. 196:1363-1368(1993).
RN [2]
RP PROTEIN SEQUENCE OF 131-146, AND AMIDATION AT VAL-146.
RC TISSUE=Leukocyte;
RX PubMed=8335113; DOI=10.1016/0014-5793(93)80175-t;
RA Kokryakov V.N., Harwig S.S.L., Panyutich E.A., Shevchenko A.A.,
RA Aleshina G.M., Shamova O.V., Korneva H.A., Lehrer R.I.;
RT "Protegrins: leukocyte antimicrobial peptides that combine features of
RT corticostatic defensins and tachyplesins.";
RL FEBS Lett. 327:231-236(1993).
CC -!- FUNCTION: Microbicidal activity. Active against E.coli, Listeria
CC monocytogenes and C.albicans, in vitro.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR EMBL; L24745; AAA31061.1; -; mRNA.
DR PIR; JN0900; JN0900.
DR RefSeq; NP_001123438.1; NM_001129966.1.
DR PDB; 2MUH; NMR; -; A=131-146.
DR PDBsum; 2MUH; -.
DR AlphaFoldDB; P32195; -.
DR BMRB; P32195; -.
DR SMR; P32195; -.
DR PeptideAtlas; P32195; -.
DR GeneID; 100170125; -.
DR CTD; 100170125; -.
DR InParanoid; P32195; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR InterPro; IPR001894; Cathelicidin-like.
DR InterPro; IPR018216; Cathelicidin_CS.
DR InterPro; IPR046350; Cystatin_sf.
DR PANTHER; PTHR10206; PTHR10206; 1.
DR SUPFAM; SSF54403; SSF54403; 1.
DR PROSITE; PS00946; CATHELICIDINS_1; 1.
DR PROSITE; PS00947; CATHELICIDINS_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Amidation; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT PROPEP 30..130
FT /evidence="ECO:0000269|PubMed:8335113"
FT /id="PRO_0000004746"
FT PEPTIDE 131..146
FT /note="Protegrin-2"
FT /id="PRO_0000004747"
FT REGION 61..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 146
FT /note="Valine amide"
FT /evidence="ECO:0000305|PubMed:8335113"
FT DISULFID 85..96
FT /evidence="ECO:0000250"
FT DISULFID 107..124
FT /evidence="ECO:0000250"
FT DISULFID 136..145
FT /evidence="ECO:0000250"
FT DISULFID 138..143
FT /evidence="ECO:0000250"
FT STRAND 136..139
FT /evidence="ECO:0007829|PDB:2MUH"
FT STRAND 142..145
FT /evidence="ECO:0007829|PDB:2MUH"
SQ SEQUENCE 147 AA; 16478 MW; 698429DFFEC40466 CRC64;
METQRASLCL GRWSLWLLLL ALVVPSASAQ ALSYREAVLR AVDRLNEQSS EANLYRLLEL
DQPPKADEDP GTPKPVSFTV KETVCPRPTR QPPELCDFKE NGRVKQCVGT VTLDQIKDPL
DITCNEVQGV RGGRLCYCRR RFCICVG
