ID   PG34_MYCTU              Reviewed;         515 AA.
AC   P9WIF3; L0T9E6; Q50594;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Uncharacterized PE-PGRS family protein PE_PGRS34;
GN   Name=PE_PGRS34; OrderedLocusNames=Rv1840c;
GN   ORFNames=MTCY1A11.04, MTCY359.33;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PE family. PGRS subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP44606.1; -; Genomic_DNA.
DR   PIR; H70663; H70663.
DR   RefSeq; WP_003904712.1; NZ_KK339370.1.
DR   RefSeq; YP_177847.1; NC_000962.3.
DR   AlphaFoldDB; P9WIF3; -.
DR   STRING; 83332.Rv1840c; -.
DR   PaxDb; P9WIF3; -.
DR   DNASU; 885753; -.
DR   GeneID; 885753; -.
DR   KEGG; mtu:Rv1840c; -.
DR   PATRIC; fig|83332.111.peg.2046; -.
DR   TubercuList; Rv1840c; -.
DR   eggNOG; COG0657; Bacteria.
DR   OMA; EESHINC; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000084; PE-PGRS_N.
DR   Pfam; PF00934; PE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..515
FT                   /note="Uncharacterized PE-PGRS family protein PE_PGRS34"
FT                   /id="PRO_0000216165"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..93
FT                   /note="PE"
FT                   /evidence="ECO:0000255"
FT   REGION          349..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          463..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   515 AA;  43916 MW;  2EDC8B6C6D28B7F3 CRC64;
     MSFVVAAPEV VVAAASDLAG IGSAIGAANA AAAVPTMGVL AAGADEVSAA VADLFGAHAQ
     AYQALSAQAA LFHEQFVHAM TAGAGAYAGA EAADAAALDV LNGPFQALFG RPLIGDGANG
     APGQPGGPGG LLYGNGGNGG NGGIGQPGGA GGDAGLIGNG GNGGIGGPGA TGLAGGAGGV
     GGLLFGDGGN GGAGGLGTGP VGATGGIGGP GGAAVGLFGH GGAGGAGGLG KAGFAGGAGG
     TGGTGGLLYG NGGNGGNVPS GAADGGAGGD ARLIGNGGDG GSVGAAPTGI GNGGNGGNGG
     WLYGDGGSGG STLQGFSDGG TGGNAGMFGD GGNGGFSFFD GNGGDGGTGG TLIGNGGDGG
     NSVQTDGFLR GHGGDGGNAV GLIGNGGAGG AGSAGTGVFA PGGGSGGNGG NGALLVGNGG
     AGGSGGPTQI PSVAVPVTGA GGTGGNGGTA GLIGNGGNGG AAGVSGDGTP GTGGNGGYAQ
     LIGDGGDGGP GDSGGPGGSG GTGGTLAGQN GSPGG