ID   PG47_MYCTU              Reviewed;         525 AA.
AC   Q79FB3;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=PE-PGRS family protein PE_PGRS47 {ECO:0000305};
GN   Name=PE_PGRS47 {ECO:0000312|EMBL:CCP45540.1};
GN   OrderedLocusNames=Rv2741 {ECO:0000312|EMBL:CCP45540.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX   PubMed=27562263; DOI=10.1038/nmicrobiol.2016.133;
RA   Saini N.K., Baena A., Ng T.W., Venkataswamy M.M., Kennedy S.C.,
RA   Kunnath-Velayudhan S., Carreno L.J., Xu J., Chan J., Larsen M.H.,
RA   Jacobs W.R. Jr., Porcelli S.A.;
RT   "Suppression of autophagy and antigen presentation by Mycobacterium
RT   tuberculosis PE_PGRS47.";
RL   Nat. Microbiol. 1:16133-16133(2016).
CC   -!- FUNCTION: Contributes to evasion of both innate and adaptive immunity.
CC       Inhibits autophagy in infected host phagocytes and inhibits major
CC       histocompatibility complex (MHC) class II antigen presentation by
CC       mycobacteria-infected dendritic cells. Has an important role in the
CC       growth and survival of M.tuberculosis, particularly during
CC       intracellular growth and in the later chronic phase of infection.
CC       {ECO:0000269|PubMed:27562263}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27562263}. Cell
CC       surface {ECO:0000269|PubMed:27562263}. Host cytoplasm, host cytosol
CC       {ECO:0000269|PubMed:27562263}. Note=Loosely attached to the cell
CC       surface, with the potential to detach during growth within infected
CC       cells. {ECO:0000269|PubMed:27562263}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutant is attenuated in vitro and in
CC       vivo, and shows enhanced MHC class II-restricted antigen presentation
CC       during in vivo infection of mice. Also shows a reduced capability to
CC       inhibit autophagy and an increased acidification and lysosomal fusion
CC       of phagosomes during infection of phagocytic cells.
CC       {ECO:0000269|PubMed:27562263}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PE family. PGRS subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP45540.1; -; Genomic_DNA.
DR   RefSeq; WP_010886154.1; NC_000962.3.
DR   RefSeq; YP_177902.1; NC_000962.3.
DR   AlphaFoldDB; Q79FB3; -.
DR   STRING; 83332.Rv2741; -.
DR   PaxDb; Q79FB3; -.
DR   GeneID; 888339; -.
DR   KEGG; mtu:Rv2741; -.
DR   PATRIC; fig|83332.12.peg.3054; -.
DR   TubercuList; Rv2741; -.
DR   eggNOG; COG3391; Bacteria.
DR   InParanoid; Q79FB3; -.
DR   OMA; YGEREEY; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000084; PE-PGRS_N.
DR   Pfam; PF00934; PE; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Reference proteome; Secreted; Virulence.
FT   CHAIN           1..525
FT                   /note="PE-PGRS family protein PE_PGRS47"
FT                   /id="PRO_5004287628"
FT   DOMAIN          1..93
FT                   /note="PE"
FT                   /evidence="ECO:0000255"
FT   REGION          506..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   525 AA;  44210 MW;  E727C9F593DB78FC CRC64;
     MSFVIAAPEF LTAAAMDLAS IGSTVSAASA AASAPTVAIL AAGADEVSIA VAALFGMHGQ
     AYQALSVQAS AFHQQFVQAL TAGAYSYASA EAAAVTPLQQ LVDVINAPFR SALGRPLIGN
     GANGKPGTGQ DGGAGGLLYG SGGNGGSGLA GSGQKGGNGG AAGLFGNGGA GGAGASNQAG
     NGGAGGNGGA GGLIWGTAGT GGNGGFTTFL DAAGGAGGAG GAGGLFGAGG AGGVGGAALG
     GGAQAAGGNG GAGGVGGLFG AGGAGGAGGF SDTGGTGGAG GAGGLFGPGG GSGGVGGFGD
     TGGTGGDGGS GGLFGVGGAG GHGGFGSAAG GDGGAGGAGG TVFGSGGAGG AGGVATVAGH
     GGHGGNAGLL YGTGGAGGAG GFGGFGGDGG DGGIGGLVGS GGAGGSGGTG TLSGGRGGAG
     GNAGTFYGSG GAGGAGGESD NGDGGNGGVG GKAGLVGEGG NGGDGGATIA GKGGSGGNGG
     NAWLTGQGGN GGNAAFGKAG TGSVGVGGAG GLLEGQNGEN GLLPS