ID   PGA15_CANAL             Reviewed;         165 AA.
AC   Q5A1E1; A0A1D8PMM5;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Probable cell wall protein PGA15;
DE   AltName: Full=Predicted GPI-anchored protein 15;
DE   Flags: Precursor;
GN   Name=PGA15; OrderedLocusNames=CAALFM_C406560WA;
GN   ORFNames=CaO19.10396, CaO19.2878;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=17238235; DOI=10.1002/yea.1444;
RA   Moreno I., Castillo L., Sentandreu R., Valentin E.;
RT   "Global transcriptional profiling of Candida albicans cwt1 null mutant.";
RL   Yeast 24:357-370(2007).
RN   [6]
RP   INDUCTION.
RX   PubMed=23208712; DOI=10.1128/aac.02040-12;
RA   Silva L.V., Sanguinetti M., Vandeputte P., Torelli R., Rochat B.,
RA   Sanglard D.;
RT   "Milbemycins: more than efflux inhibitors for fungal pathogens.";
RL   Antimicrob. Agents Chemother. 57:873-886(2013).
CC   -!- FUNCTION: Probable GPI-anchored cell wall protein that may be involved
CC       in cell wall organization, hyphal growth, as well as in virulence.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}. Membrane
CC       {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
CC   -!- INDUCTION: Up-regulated upon milbemycin A3 oxim derivative (A3Ox)
CC       treatment. Expression is also regulated by CWT1.
CC       {ECO:0000269|PubMed:17238235, ECO:0000269|PubMed:23208712}.
CC   -!- PTM: The GPI-anchor is attached to the protein in the endoplasmic
CC       reticulum and serves to target the protein to the cell surface. There,
CC       the glucosamine-inositol phospholipid moiety is cleaved off and the
CC       GPI-modified mannoprotein is covalently attached via its lipidless GPI
CC       glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IHD1 family. {ECO:0000305}.
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DR   EMBL; CP017626; AOW29379.1; -; Genomic_DNA.
DR   RefSeq; XP_715534.1; XM_710441.1.
DR   AlphaFoldDB; Q5A1E1; -.
DR   STRING; 237561.Q5A1E1; -.
DR   GeneID; 3642781; -.
DR   KEGG; cal:CAALFM_C406560WA; -.
DR   CGD; CAL0000184232; PGA15.
DR   VEuPathDB; FungiDB:C4_06560W_A; -.
DR   HOGENOM; CLU_141124_0_0_1; -.
DR   OMA; NDNQNTG; -.
DR   PRO; PR:Q5A1E1; -.
DR   Proteomes; UP000000559; Chromosome 4.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell wall; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..143
FT                   /note="Probable cell wall protein PGA15"
FT                   /id="PRO_0000424737"
FT   PROPEP          144..165
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424738"
FT   LIPID           143
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   165 AA;  18105 MW;  CD05FB659C2018DF CRC64;
     MKFIIILFTL ISIVTAAQRI YNKDYSYYGC NSYCDKASDQ EDACGYYDDD VSYQDYYGCL
     CGNEIFLSNL KSCDCFTSII ASVSKSVCSK ATEDSDWGYY DDSTSSIMDF FTADNTPASN
     TGMTTQTDGA INDNQNTGSK TSSGAANYLT SFSIGTFFVF VLGLI