ID   PGA16_CANAL             Reviewed;         107 AA.
AC   Q5AHE8; A0A1D8PH15; Q5AHS3;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Virulence factor PGA16;
DE   AltName: Full=Predicted GPI-anchored protein 16;
DE   Flags: Precursor;
GN   Name=PGA16; OrderedLocusNames=CAALFM_C203720WA;
GN   ORFNames=CaO19.8468, CaO19.848;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=24610660; DOI=10.1128/ec.00051-14;
RA   Wilson D., Mayer F.L., Miramon P., Slesiona S., Jacobsen I.D., Hube B.;
RT   "Candida albicans specific genes: distinct roles in host-pathogen
RT   interactions.";
RL   Eukaryot. Cell 13:977-989(2014).
CC   -!- FUNCTION: Cell surface GPI-anchored protein required for virulence.
CC       Mediates hyphal ramification which is important for the interaction
CC       with host cells. {ECO:0000269|PubMed:24610660}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Leads to strong defects in host cell damage in a
CC       model of human oral epithelial cells, increased survival of infected
CC       mice, and aberrant filamentous morphology.
CC       {ECO:0000269|PubMed:24610660}.
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DR   EMBL; CP017624; AOW27403.1; -; Genomic_DNA.
DR   RefSeq; XP_720972.1; XM_715879.1.
DR   AlphaFoldDB; Q5AHE8; -.
DR   GeneID; 3637373; -.
DR   KEGG; cal:CAALFM_C203720WA; -.
DR   CGD; CAL0000192099; PGA16.
DR   VEuPathDB; FungiDB:C2_03720W_A; -.
DR   HOGENOM; CLU_2236222_0_0_1; -.
DR   OMA; FQIVYIL; -.
DR   PHI-base; PHI:4657; -.
DR   PRO; PR:Q5AHE8; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Signal; Virulence.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..76
FT                   /note="Virulence factor PGA16"
FT                   /id="PRO_0000424919"
FT   PROPEP          77..107
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424920"
FT   REGION          26..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           76
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        56
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   107 AA;  11343 MW;  4F1733DEA78F33C5 CRC64;
     MRVFQIVYIL IISNLIYATS GGGTSSHHHK NDNNIADNTN NNNNNNNNNN NNNITNATTT
     RTVTTSTKTK THTGGGVAAM GGILGQNGWF YGDAGLMAAI FGAMLLL