ID   PGA17_CANAL             Reviewed;         557 AA.
AC   Q5AHA4; A0A1D8PGU3;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Predicted GPI-anchored protein 17;
DE   Flags: Precursor;
GN   Name=PGA17; OrderedLocusNames=CAALFM_C203350WA;
GN   ORFNames=CaO19.8512, CaO19.893;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=16987174; DOI=10.1111/j.1365-2958.2006.05367.x;
RA   Bennett R.J., Johnson A.D.;
RT   "The role of nutrient regulation and the Gpa2 protein in the mating
RT   pheromone response of C. albicans.";
RL   Mol. Microbiol. 62:100-119(2006).
RN   [6]
RP   INDUCTION.
RX   PubMed=17164403; DOI=10.1074/mcp.m600210-mcp200;
RA   Fernandez-Arenas E., Cabezon V., Bermejo C., Arroyo J., Nombela C.,
RA   Diez-Orejas R., Gil C.;
RT   "Integrated proteomics and genomics strategies bring new insight into
RT   Candida albicans response upon macrophage interaction.";
RL   Mol. Cell. Proteomics 6:460-478(2007).
RN   [7]
RP   CLEAVAGE BY KEX2.
RX   PubMed=18625069; DOI=10.1186/1471-2180-8-116;
RA   Bader O., Krauke Y., Hube B.;
RT   "Processing of predicted substrates of fungal Kex2 proteinases from Candida
RT   albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris.";
RL   BMC Microbiol. 8:116-116(2008).
RN   [8]
RP   INDUCTION.
RX   PubMed=22544909; DOI=10.1128/ec.00103-12;
RA   Fanning S., Xu W., Solis N., Woolford C.A., Filler S.G., Mitchell A.P.;
RT   "Divergent targets of Candida albicans biofilm regulator Bcr1 in vitro and
RT   in vivo.";
RL   Eukaryot. Cell 11:896-904(2012).
RN   [9]
RP   INDUCTION.
RX   PubMed=23208712; DOI=10.1128/aac.02040-12;
RA   Silva L.V., Sanguinetti M., Vandeputte P., Torelli R., Rochat B.,
RA   Sanglard D.;
RT   "Milbemycins: more than efflux inhibitors for fungal pathogens.";
RL   Antimicrob. Agents Chemother. 57:873-886(2013).
CC   -!- FUNCTION: Predicted GPI-anchored protein which may have a role during
CC       host infection.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- INDUCTION: Up-regulated upon milbemycins A3 oxim derivative (A3Ox)
CC       treatment, upon interaction of cells with host macrophages, and during
CC       oralpharyngeal candidiasis. Repressed by alpha pheromone.
CC       {ECO:0000269|PubMed:16987174, ECO:0000269|PubMed:17164403,
CC       ECO:0000269|PubMed:22544909, ECO:0000269|PubMed:23208712}.
CC   -!- PTM: Substrate for cleavage by KEX2 in vitro.
CC       {ECO:0000269|PubMed:18625069}.
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DR   EMBL; CP017624; AOW27371.1; -; Genomic_DNA.
DR   RefSeq; XP_721014.2; XM_715921.2.
DR   AlphaFoldDB; Q5AHA4; -.
DR   STRING; 237561.Q5AHA4; -.
DR   GeneID; 3637391; -.
DR   KEGG; cal:CAALFM_C203350WA; -.
DR   CGD; CAL0000193395; PGA17.
DR   VEuPathDB; FungiDB:C2_03350W_A; -.
DR   eggNOG; ENOG502RQ5Y; Eukaryota.
DR   HOGENOM; CLU_438699_0_0_1; -.
DR   InParanoid; Q5AHA4; -.
DR   OrthoDB; 1000497at2759; -.
DR   PRO; PR:Q5AHA4; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell membrane; Coiled coil; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..533
FT                   /note="Predicted GPI-anchored protein 17"
FT                   /id="PRO_0000424921"
FT   PROPEP          534..557
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424922"
FT   COILED          320..355
FT                   /evidence="ECO:0000255"
FT   LIPID           533
FT                   /note="GPI-anchor amidated asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        116
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        284
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        309
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        376
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        471
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        520
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   557 AA;  59541 MW;  48421278F53A9E3C CRC64;
     MKFSTVFTAI FALGTAVSAQ QVVTPASDPL ALELSQRNLD KLYELQERDL FSIVEGLFSS
     INYTSILDSI DYESIAGWTN NLLVENNNIE YLDNILNFLG DTDLVPFAVS YLLSNNETRN
     IVGEVVIEAL PLIKDIDPTP IFVALKNSGL AYVLVADLIK NPNTVPFVKQ VVVDLLDEGS
     FGLGDLFGGS SEATTTAVAI DSLATINTNI DLTVAAAPTT KAQSIGSIDT ASLAVLFSEA
     RTANGNGATK VANTVAVTAQ VTAQVTNVGT TAKATKAVAT GEINYSGITG PAYESLPPTQ
     FGSVPTSINY SALSQISGAL RKREYNDAVE AALRDIQKRE EGIDDVEIAL RKMKRDNIED
     LLTTIFASVA RSNLLNTTIQ YLVTDQRFES TVVELLQGVF ENIGSTLTGI LDTDWSALQP
     LVSSLLNSGL LTDFISRAFN DDELKAVLWN DITSIFKRDM AFRDEIVKRS NGTITSLPVS
     DFITGVATET SALDGADGTL SSLDVTAFIN TVSHSFITSN ASSSAVITIQ SDNAGSSYGP
     GFYSTIFAVF GLFAMMI