ID   PGA19_CANAL             Reviewed;         229 AA.
AC   Q5AD34; A0A1D8PG87;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 2.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Predicted GPI-anchored protein 19;
DE   Flags: Precursor;
GN   Name=PGA19; OrderedLocusNames=CAALFM_C200910WA;
GN   ORFNames=CaO19.2033, CaO19.9581;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=17164403; DOI=10.1074/mcp.m600210-mcp200;
RA   Fernandez-Arenas E., Cabezon V., Bermejo C., Arroyo J., Nombela C.,
RA   Diez-Orejas R., Gil C.;
RT   "Integrated proteomics and genomics strategies bring new insight into
RT   Candida albicans response upon macrophage interaction.";
RL   Mol. Cell. Proteomics 6:460-478(2007).
RN   [6]
RP   INDUCTION.
RX   PubMed=23208712; DOI=10.1128/aac.02040-12;
RA   Silva L.V., Sanguinetti M., Vandeputte P., Torelli R., Rochat B.,
RA   Sanglard D.;
RT   "Milbemycins: more than efflux inhibitors for fungal pathogens.";
RL   Antimicrob. Agents Chemother. 57:873-886(2013).
CC   -!- FUNCTION: Predicted GPI-anchored protein which may have a role during
CC       host infection.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- INDUCTION: Up-regulated upon interaction of cells with host macrophages
CC       and upon milbemycins A3 oxim derivative (A3Ox) treatment.
CC       {ECO:0000269|PubMed:17164403, ECO:0000269|PubMed:23208712}.
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DR   EMBL; CP017624; AOW27143.1; -; Genomic_DNA.
DR   RefSeq; XP_719482.2; XM_714389.2.
DR   AlphaFoldDB; Q5AD34; -.
DR   STRING; 237561.Q5AD34; -.
DR   GeneID; 3638894; -.
DR   KEGG; cal:CAALFM_C200910WA; -.
DR   CGD; CAL0000177109; PGA19.
DR   VEuPathDB; FungiDB:C2_00910W_A; -.
DR   HOGENOM; CLU_1219554_0_0_1; -.
DR   OrthoDB; 1734440at2759; -.
DR   PRO; PR:Q5AD34; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Signal; Virulence.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..208
FT                   /note="Predicted GPI-anchored protein 19"
FT                   /id="PRO_0000424923"
FT   PROPEP          209..229
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424924"
FT   REGION          63..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        78..92
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           208
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        87
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        184
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        189
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   229 AA;  26090 MW;  668CA73A372B9F85 CRC64;
     MFSTTSIVLW FTILLPVTLP VSIDNRDLLL KRHVEPNDIQ FFNQGVRSSL SYIYQKRDVS
     DSDNEQVLRK SKKKKKTTST GTPGNENTTD FASAQEFEKW EGDREGWQIS AGLYFDKAIA
     SDSCDSDSED EDEGRKKFWI FTDDAPVDNE NLIVSSEDKL ELNYISSGKN LEGLTKVIRK
     AKGNSTTYNQ SKIKFNVDAQ GEDQFESGFG SLIPYNSFYL YILLFCIIF