PGA1_CANAL
ID PGA1_CANAL Reviewed; 132 AA.
AC Q5ACL7; A0A1D8PU92;
DT 11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Predicted GPI-anchored protein 1;
DE Flags: Precursor;
GN Name=PGA1; Synonyms=KRE102; OrderedLocusNames=CAALFM_CR10480WA;
GN ORFNames=CaO19.7625;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP PREDICTION OF GPI-ANCHOR.
RX PubMed=12845604; DOI=10.1002/yea.1007;
RA De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT "Genome-wide identification of fungal GPI proteins.";
RL Yeast 20:781-796(2003).
RN [5]
RP INDUCTION.
RX PubMed=16455273; DOI=10.1016/j.fgb.2005.12.002;
RA Castillo L., Martinez A.I., Garcera A., Garcia-Martinez J.,
RA Ruiz-Herrera J., Valentin E., Sentandreu R.;
RT "Genomic response programs of Candida albicans following protoplasting and
RT regeneration.";
RL Fungal Genet. Biol. 43:124-134(2006).
RN [6]
RP FUNCTION.
RX PubMed=20406396; DOI=10.1111/j.1439-0507.2010.01883.x;
RA Hashash R., Younes S., Bahnan W., El Koussa J., Maalouf K., Dimassi H.I.,
RA Khalaf R.A.;
RT "Characterisation of Pga1, a putative Candida albicans cell wall protein
RT necessary for proper adhesion and biofilm formation.";
RL Mycoses 54:491-500(2011).
CC -!- FUNCTION: Plays a role in cell wall stability and rigidity. Required
CC for normal adhesion to host cells and for adherence during biofilm
CC formation. Necessary for proper oxidative stress response.
CC {ECO:0000269|PubMed:20406396}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- INDUCTION: Induced during cell wall regeneration following
CC protoplasting. {ECO:0000269|PubMed:16455273}.
CC -!- SIMILARITY: Belongs to the KRE1 family. {ECO:0000305}.
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DR EMBL; CP017630; AOW31697.1; -; Genomic_DNA.
DR RefSeq; XP_719386.1; XM_714293.1.
DR AlphaFoldDB; Q5ACL7; -.
DR GeneID; 3638980; -.
DR KEGG; cal:CAALFM_CR10480WA; -.
DR CGD; CAL0000175225; PGA1.
DR VEuPathDB; FungiDB:CR_10480W_A; -.
DR eggNOG; ENOG502SASR; Eukaryota.
DR HOGENOM; CLU_156717_0_0_1; -.
DR InParanoid; Q5ACL7; -.
DR OMA; QSFKTTY; -.
DR OrthoDB; 1637534at2759; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044406; P:adhesion of symbiont to host; IMP:CGD.
DR GO; GO:0043709; P:cell adhesion involved in single-species biofilm formation; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
DR GO; GO:0031505; P:fungal-type cell wall organization; IMP:CGD.
DR GO; GO:1900429; P:negative regulation of filamentous growth of a population of unicellular organisms; IMP:CGD.
DR InterPro; IPR031452; Kre1.
DR Pfam; PF17056; KRE1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell wall biogenesis/degradation; Glycoprotein; GPI-anchor;
KW Lipoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Virulence.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..100
FT /note="Predicted GPI-anchored protein 1"
FT /id="PRO_0000424632"
FT PROPEP 101..132
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000424633"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT LIPID 100
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 132 AA; 13804 MW; D685519AEB19199D CRC64;
MNFNKFLIII SCYLACVFAL ANQNDGGDDD SKTKKTTTWV WVTTTIGGQL ATISTAYSQK
FISTHSSEDA KSVASGEIGL GSLSGSVGGI KTYSQTTITN ANIAPSNNNV FLGIESLYTG
IVGGIVLILG LL
