ID   PGA22_CANAL             Reviewed;         169 AA.
AC   Q59V02; A0A1D8PS64;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Probable GPI-anchored adhesin-like protein PGA22;
DE   AltName: Full=Predicted GPI-anchored protein 22;
DE   Flags: Precursor;
GN   Name=PGA22; OrderedLocusNames=CAALFM_CR02290WA;
GN   ORFNames=CaO19.11223, CaO19.3738;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   FUNCTION.
RX   PubMed=21496229; DOI=10.1186/1471-2164-12-192;
RA   Chaudhuri R., Ansari F.A., Raghunandanan M.V., Ramachandran S.;
RT   "FungalRV: adhesin prediction and immunoinformatics portal for human fungal
RT   pathogens.";
RL   BMC Genomics 12:192-192(2011).
RN   [6]
RP   INDUCTION.
RX   PubMed=23208712; DOI=10.1128/aac.02040-12;
RA   Silva L.V., Sanguinetti M., Vandeputte P., Torelli R., Rochat B.,
RA   Sanglard D.;
RT   "Milbemycins: more than efflux inhibitors for fungal pathogens.";
RL   Antimicrob. Agents Chemother. 57:873-886(2013).
CC   -!- FUNCTION: Putative adhesin which may be involved in cell adhesion and
CC       virulence. {ECO:0000250, ECO:0000269|PubMed:21496229}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- INDUCTION: Up-regulated upon milbemycins A3 oxim derivative (A3Ox)
CC       treatment. {ECO:0000269|PubMed:23208712}.
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DR   EMBL; CP017630; AOW30978.1; -; Genomic_DNA.
DR   RefSeq; XP_713426.1; XM_708333.1.
DR   AlphaFoldDB; Q59V02; -.
DR   STRING; 237561.Q59V02; -.
DR   GeneID; 3644939; -.
DR   KEGG; cal:CAALFM_CR02290WA; -.
DR   CGD; CAL0000188460; PGA22.
DR   VEuPathDB; FungiDB:CR_02290W_A; -.
DR   HOGENOM; CLU_1578297_0_0_1; -.
DR   PRO; PR:Q59V02; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell adhesion; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal; Virulence.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..140
FT                   /note="Probable GPI-anchored adhesin-like protein PGA22"
FT                   /id="PRO_0000424925"
FT   PROPEP          141..169
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424926"
FT   LIPID           140
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        87
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        111
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        118
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   169 AA;  17335 MW;  500D55EE8BF20B6B CRC64;
     MKYSTLAWLV IASYTVFAQD GTSVTGYTTT IVIPGSPPAG AGTAHGDTEN TGTVHTTEHL
     TGTEETHTTG ATPETTTIVA PTTTHENTTT HETSVENTAT VHHNTTTLHH NTTTIHPNAT
     GTETHTETGT GTLTGTGTEG PALTTTTVAE AFSLAAGASL GYLVALLFL