PGA23_CANAL
ID PGA23_CANAL Reviewed; 282 AA.
AC Q59V01; A0A1D8PS63; Q59V37;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Predicted GPI-anchored protein 23;
DE Flags: Precursor;
GN Name=PGA23; Synonyms=PGR23, SLP99; OrderedLocusNames=CAALFM_CR02280WA;
GN ORFNames=CaO19.11225, CaO19.3740;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=12912891; DOI=10.1128/ec.2.4.718-728.2003;
RA Ramon A.M., Fonzi W.A.;
RT "Diverged binding specificity of Rim101p, the Candida albicans ortholog of
RT PacC.";
RL Eukaryot. Cell 2:718-728(2003).
RN [5]
RP PREDICTION OF GPI-ANCHOR.
RX PubMed=12845604; DOI=10.1002/yea.1007;
RA De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT "Genome-wide identification of fungal GPI proteins.";
RL Yeast 20:781-796(2003).
RN [6]
RP INDUCTION.
RX PubMed=15269278; DOI=10.1091/mbc.e04-02-0144;
RA Harcus D., Nantel A., Marcil A., Rigby T., Whiteway M.;
RT "Transcription profiling of cyclic AMP signaling in Candida albicans.";
RL Mol. Biol. Cell 15:4490-4499(2004).
RN [7]
RP INDUCTION.
RX PubMed=15814841; DOI=10.1091/mbc.e05-01-0071;
RA Garcia-Sanchez S., Mavor A.L., Russell C.L., Argimon S., Dennison P.,
RA Enjalbert B., Brown A.J.;
RT "Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the
RT fungal pathogen, Candida albicans.";
RL Mol. Biol. Cell 16:2913-2925(2005).
RN [8]
RP INDUCTION, AND FUNCTION.
RX PubMed=17042758; DOI=10.1111/j.1567-1364.2006.00130.x;
RA Sohn K., Senyurek I., Fertey J., Konigsdorfer A., Joffroy C., Hauser N.,
RA Zelt G., Brunner H., Rupp S.;
RT "An in vitro assay to study the transcriptional response during adherence
RT of Candida albicans to different human epithelia.";
RL FEMS Yeast Res. 6:1085-1093(2006).
RN [9]
RP INDUCTION.
RX PubMed=23208712; DOI=10.1128/aac.02040-12;
RA Silva L.V., Sanguinetti M., Vandeputte P., Torelli R., Rochat B.,
RA Sanglard D.;
RT "Milbemycins: more than efflux inhibitors for fungal pathogens.";
RL Antimicrob. Agents Chemother. 57:873-886(2013).
CC -!- FUNCTION: Probable cell surface protein involved in the process of
CC adhesion and early events of invasion. {ECO:0000269|PubMed:17042758}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- INDUCTION: Up-regulated when cells are growing in an adherent manner
CC and upon milbemycins A3 oxim derivative (A3Ox) treatment. Expression is
CC also regulated by CYR1, RIM101 and SSN6. {ECO:0000269|PubMed:12912891,
CC ECO:0000269|PubMed:15269278, ECO:0000269|PubMed:15814841,
CC ECO:0000269|PubMed:17042758, ECO:0000269|PubMed:23208712}.
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DR EMBL; CP017630; AOW30977.1; -; Genomic_DNA.
DR RefSeq; XP_713428.1; XM_708335.2.
DR AlphaFoldDB; Q59V01; -.
DR STRING; 237561.Q59V01; -.
DR GeneID; 3644941; -.
DR KEGG; cal:CAALFM_CR02280WA; -.
DR CGD; CAL0000196898; PGA23.
DR VEuPathDB; FungiDB:CR_02280W_A; -.
DR HOGENOM; CLU_1042056_0_0_1; -.
DR OMA; SARGAHE; -.
DR OrthoDB; 1902354at2759; -.
DR PRO; PR:Q59V01; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cell adhesion; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal; Virulence.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..259
FT /note="Predicted GPI-anchored protein 23"
FT /id="PRO_0000424927"
FT PROPEP 260..282
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000424928"
FT REGION 163..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 259
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 180
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 282 AA; 24390 MW; 75AE9831098891B8 CRC64;
MRVSTLVLST SIIPIATALN ISPFHNIEKK DILADAASAA GGAAAAVTSG AVGAANTVAS
GAAGAADTAT SGAAGIANTV ASGAAGAADT ATSGAAGAAK TATSGAAGAA DTATSGAVGA
AKTATSGAAG AAKTATSGAA GAASGAETAA GAAASGAETA AAGQETSGAG SLVGGSGSSN
STSPSGGSGS SNGTSSGSGS GSGAGVGSGS GSGSGSRGSI TGNSVATGAS SGPAGLGISS
SISQSTTRQL QTSGSSNSSS SAGMGNVVVG MNAVALAALV LI
