PGA26_CANAL
ID PGA26_CANAL Reviewed; 131 AA.
AC Q5AA09; A0A1D8PDQ4;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 2.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Predicted GPI-anchored protein 26;
DE Flags: Precursor;
GN Name=PGA26; OrderedLocusNames=CAALFM_C105760CA;
GN ORFNames=CaO19.10012, CaO19.2475;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP PREDICTION OF GPI-ANCHOR.
RX PubMed=12845604; DOI=10.1002/yea.1007;
RA De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT "Genome-wide identification of fungal GPI proteins.";
RL Yeast 20:781-796(2003).
RN [5]
RP INDUCTION.
RX PubMed=15387822; DOI=10.1111/j.1365-2958.2004.04214.x;
RA Lan C.Y., Rodarte G., Murillo L.A., Jones T., Davis R.W., Dungan J.,
RA Newport G., Agabian N.;
RT "Regulatory networks affected by iron availability in Candida albicans.";
RL Mol. Microbiol. 53:1451-1469(2004).
RN [6]
RP INDUCTION.
RX PubMed=16455273; DOI=10.1016/j.fgb.2005.12.002;
RA Castillo L., Martinez A.I., Garcera A., Garcia-Martinez J.,
RA Ruiz-Herrera J., Valentin E., Sentandreu R.;
RT "Genomic response programs of Candida albicans following protoplasting and
RT regeneration.";
RL Fungal Genet. Biol. 43:124-134(2006).
RN [7]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21439008; DOI=10.1111/j.1567-1364.2011.00727.x;
RA Laforet L., Moreno I., Sanchez-Fresneda R., Martinez-Esparza M.,
RA Martinez J.P., Arguelles J.C., de Groot P.W., Valentin-Gomez E.;
RT "Pga26 mediates filamentation and biofilm formation and is required for
RT virulence in Candida albicans.";
RL FEMS Yeast Res. 11:389-397(2011).
RN [8]
RP INDUCTION.
RX PubMed=21592964; DOI=10.1074/jbc.m111.233569;
RA Singh R.P., Prasad H.K., Sinha I., Agarwal N., Natarajan K.;
RT "Cap2-HAP complex is a critical transcriptional regulator that has dual but
RT contrasting roles in regulation of iron homeostasis in Candida albicans.";
RL J. Biol. Chem. 286:25154-25170(2011).
CC -!- FUNCTION: GPI-anchored protein involved in proper cell wall integrity.
CC Does not seem to be directly involved in the synthesis of the cell
CC wall. Required for normal virulence in a mouse model of disseminated
CC candidiasis. {ECO:0000269|PubMed:21439008}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- INDUCTION: Induced during cell wall regeneration. Expression is also
CC increased under high-iron conditions. Repressed by the HAP43
CC transcription factor. {ECO:0000269|PubMed:15387822,
CC ECO:0000269|PubMed:16455273, ECO:0000269|PubMed:21592964}.
CC -!- DISRUPTION PHENOTYPE: Leads to hyperfilamentation, increased biofilm
CC formation and reduced virulence in a mouse model of disseminated
CC candidiasis. Leads also to increased susceptibility to antifungals
CC (fluconazol, posaconazol or amphotericin B) that target the plasma
CC membrane and to altered sensitivities to environmental (heat, osmotic
CC and oxidative) stresses. {ECO:0000269|PubMed:21439008}.
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DR EMBL; CP017623; AOW26240.1; -; Genomic_DNA.
DR RefSeq; XP_718496.2; XM_713403.2.
DR AlphaFoldDB; Q5AA09; -.
DR STRING; 237561.Q5AA09; -.
DR GeneID; 3639890; -.
DR KEGG; cal:CAALFM_C105760CA; -.
DR CGD; CAL0000181671; PGA26.
DR VEuPathDB; FungiDB:C1_05760C_A; -.
DR eggNOG; ENOG502RQ2F; Eukaryota.
DR HOGENOM; CLU_119130_0_0_1; -.
DR InParanoid; Q5AA09; -.
DR OrthoDB; 6357at1535326; -.
DR PHI-base; PHI:3516; -.
DR PRO; PR:Q5AA09; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Signal; Virulence.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..110
FT /note="Predicted GPI-anchored protein 26"
FT /id="PRO_0000422910"
FT PROPEP 111..131
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000422911"
FT LIPID 110
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 131 AA; 13509 MW; ECEDD1866E1E83B4 CRC64;
MHFSKIIAGS ALSSVALAEF QNGTVTTHVT ATGYTTYCPY PTTITLTICE EENICTKRPI
VVSEPTTVTV TEPCIISTSY ETTEVVVTTT LPSSLSPSSV APANVTSFEG AGSKNVASAL
VGVVAIAAAM M
