ID   PGA27_CANAL             Reviewed;         485 AA.
AC   Q5AD23; A0A1D8PG64;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 2.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Predicted GPI-anchored protein 27;
DE   Flags: Precursor;
GN   Name=PGA27; OrderedLocusNames=CAALFM_C200800CA;
GN   ORFNames=CaO19.2044, CaO19.9592;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=23208712; DOI=10.1128/aac.02040-12;
RA   Silva L.V., Sanguinetti M., Vandeputte P., Torelli R., Rochat B.,
RA   Sanglard D.;
RT   "Milbemycins: more than efflux inhibitors for fungal pathogens.";
RL   Antimicrob. Agents Chemother. 57:873-886(2013).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- INDUCTION: Up-regulated upon milbemycins A3 oxim derivative (A3Ox)
CC       treatment. {ECO:0000269|PubMed:23208712}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP017624; AOW27132.1; -; Genomic_DNA.
DR   RefSeq; XP_719493.2; XM_714400.2.
DR   AlphaFoldDB; Q5AD23; -.
DR   SMR; Q5AD23; -.
DR   STRING; 237561.Q5AD23; -.
DR   GeneID; 3638811; -.
DR   KEGG; cal:CAALFM_C200800CA; -.
DR   CGD; CAL0000194687; PGA27.
DR   VEuPathDB; FungiDB:C2_00800C_A; -.
DR   eggNOG; ENOG502RQK8; Eukaryota.
DR   HOGENOM; CLU_562557_0_0_1; -.
DR   InParanoid; Q5AD23; -.
DR   OrthoDB; 1641157at2759; -.
DR   PRO; PR:Q5AD23; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..467
FT                   /note="Predicted GPI-anchored protein 27"
FT                   /id="PRO_0000424929"
FT   PROPEP          468..485
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424930"
FT   LIPID           467
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        30
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        86
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        96
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        444
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   485 AA;  54949 MW;  C486374CFCFCBBC3 CRC64;
     MHFTSSLLAT LIWFTLPVQS LNTESRTTSN NTISILTNHF QILKDLLPYS KTSKPQIKES
     RPLIKVSRDG VPINFHRAPA IIMKSNKTDD LVRNSNKTMV LTEIKTITEF ATTTVSPTQE
     FQALQINLNT LSIETSTPTF QSHDFPPITI EDTPKTLEPE ESSDALQRDA FDQIKKLEKL
     VLDLRLEMKE QQKSFNDQLV DIYTARSIVP IYTTHIVTSA IPSYVPKEEV MVSHDSAPIV
     SRPRTDIPVS QRIDTISKHK MNGKNILNNN PPPNSVLIVP QFQFHERMAT KTEVAYMKPK
     IVWTNFPTTT ATSMFDNFIL KNLVDETDSE IDSGETELSD DYYYYYSYED DGKEDDSDEI
     TAQILLSNSE LGTKTPNFED PFEQINIEDN KVISVNTPKT KKPTTTVFGT STSALSTFES
     TIFEIPKFFY GSRRKQPSSF KNKNSTIKFD VFDWIFESGT TNEKVHGLVL VSSGVLLGTC
     LLFIL