ID   PGA32_CANAL             Reviewed;         430 AA.
AC   Q5ADQ7; A0A1D8PKP5;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Probable GPI-anchored adhesin-like protein PGA32;
DE   AltName: Full=Predicted GPI-anchored protein 32;
DE   Flags: Precursor;
GN   Name=PGA32; OrderedLocusNames=CAALFM_C307160WA;
GN   ORFNames=CaO19.14076, CaO19.6784;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=15387822; DOI=10.1111/j.1365-2958.2004.04214.x;
RA   Lan C.Y., Rodarte G., Murillo L.A., Jones T., Davis R.W., Dungan J.,
RA   Newport G., Agabian N.;
RT   "Regulatory networks affected by iron availability in Candida albicans.";
RL   Mol. Microbiol. 53:1451-1469(2004).
RN   [6]
RP   FUNCTION.
RX   PubMed=21496229; DOI=10.1186/1471-2164-12-192;
RA   Chaudhuri R., Ansari F.A., Raghunandanan M.V., Ramachandran S.;
RT   "FungalRV: adhesin prediction and immunoinformatics portal for human fungal
RT   pathogens.";
RL   BMC Genomics 12:192-192(2011).
CC   -!- FUNCTION: Putative adhesin which is involved in cell adhesion and
CC       virulence. {ECO:0000250, ECO:0000269|PubMed:21496229}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- INDUCTION: Induced upon high iron conditions.
CC       {ECO:0000269|PubMed:15387822}.
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DR   EMBL; CP017625; AOW28719.1; -; Genomic_DNA.
DR   RefSeq; XP_719880.1; XM_714787.1.
DR   AlphaFoldDB; Q5ADQ7; -.
DR   GeneID; 3638537; -.
DR   KEGG; cal:CAALFM_C307160WA; -.
DR   CGD; CAL0000193137; PGA32.
DR   VEuPathDB; FungiDB:C3_07160W_A; -.
DR   HOGENOM; CLU_591823_0_0_1; -.
DR   OMA; WITTEKS; -.
DR   OrthoDB; 1806376at2759; -.
DR   PRO; PR:Q5ADQ7; -.
DR   Proteomes; UP000000559; Chromosome 3.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell adhesion; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal; Virulence.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..401
FT                   /note="Probable GPI-anchored adhesin-like protein PGA32"
FT                   /id="PRO_0000424933"
FT   PROPEP          402..430
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424934"
FT   REGION          88..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          314..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..194
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           401
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   430 AA;  43529 MW;  0FE7A39C94AD8A85 CRC64;
     MKVSTLIIVS IPIVSGLQIK DTVGTTTENT FWYQLFGTPS RSQPAAVAAT AAGTEVQGFT
     PISTSSSSSS SSAAPWYQGL FGVGRTTLGQ VTTPSRTSTT TTTSNPIAPT TSIANSNNLF
     GTDTAPTTTT TTNARSRSRS TPVTVSGDNV LTLFGNPNLS TGNDQSNSVS KTTAETTTTS
     SAPSSSSRVQ PTVINGGGSD GVLTLFGNSE ALSNFDSTTV VDSDSTARIT PIASASASSG
     SSTKDNDSDS SSARGIKSIP NSSEFLASLI NGLGSGGGGN GSGSNTNSYK NHSTTSTTSK
     YFNSSSTATK LSSSKSIYSN STTSRSSLSV SSSSTDGGGG ANLFGSLLNS VAAVSRTLAA
     ESTLSTGTTT TSDSANSNTK DYSSYSGTIT SFPSTTGSLS GDGNKLIGGN KYLISFMWTN
     LILTMIMLFT