ID   PGA34_CANAL             Reviewed;         197 AA.
AC   Q5A210; A0A1D8PSA1;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Predicted GPI-anchored protein 34;
DE   Flags: Precursor;
GN   Name=PGA34; OrderedLocusNames=CAALFM_CR02750CA;
GN   ORFNames=CaO19.10351, CaO19.2833;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=16987174; DOI=10.1111/j.1365-2958.2006.05367.x;
RA   Bennett R.J., Johnson A.D.;
RT   "The role of nutrient regulation and the Gpa2 protein in the mating
RT   pheromone response of C. albicans.";
RL   Mol. Microbiol. 62:100-119(2006).
RN   [6]
RP   INDUCTION.
RX   PubMed=21414038; DOI=10.1111/j.1365-2958.2011.07626.x;
RA   Bonhomme J., Chauvel M., Goyard S., Roux P., Rossignol T., d'Enfert C.;
RT   "Contribution of the glycolytic flux and hypoxia adaptation to efficient
RT   biofilm formation by Candida albicans.";
RL   Mol. Microbiol. 80:995-1013(2011).
RN   [7]
RP   INDUCTION.
RX   PubMed=22544909; DOI=10.1128/ec.00103-12;
RA   Fanning S., Xu W., Solis N., Woolford C.A., Filler S.G., Mitchell A.P.;
RT   "Divergent targets of Candida albicans biofilm regulator Bcr1 in vitro and
RT   in vivo.";
RL   Eukaryot. Cell 11:896-904(2012).
CC   -!- FUNCTION: Predicted GPI-anchored protein which may have a role during
CC       host infection.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- INDUCTION: Induced in biofilms and in oralpharyngeal candidasis.
CC       Repressed by alpha pheromone. {ECO:0000269|PubMed:16987174,
CC       ECO:0000269|PubMed:21414038, ECO:0000269|PubMed:22544909}.
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DR   EMBL; CP017630; AOW31017.1; -; Genomic_DNA.
DR   RefSeq; XP_715764.2; XM_710671.2.
DR   AlphaFoldDB; Q5A210; -.
DR   GeneID; 3642579; -.
DR   KEGG; cal:CAALFM_CR02750CA; -.
DR   CGD; CAL0000179698; PGA34.
DR   VEuPathDB; FungiDB:CR_02750C_A; -.
DR   HOGENOM; CLU_1348755_0_0_1; -.
DR   PRO; PR:Q5A210; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Signal; Virulence.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..169
FT                   /note="Predicted GPI-anchored protein 34"
FT                   /id="PRO_0000424937"
FT   PROPEP          170..197
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424938"
FT   LIPID           169
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        152
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   197 AA;  19497 MW;  F36F239294681036 CRC64;
     MKFTSLICSS ILLIIPTVMA DDASSDTTII NTITITKTLY TPEESSSLLS VQLESEASVA
     SVASAASEAA ASAASIASVA SEASAASLAS ELSALAKVTE VKADVINNYN ATINSTLSSS
     TIAPKISSSS SSSSSKKHES ITSVITSSTK DNASAAVTTK TGSATSKAGA AAMAGPVPIL
     TNSIFTAGLL ALAAVLL