ID   PGA37_CANAL             Reviewed;         208 AA.
AC   Q5AK97; A0A1D8PNZ0; Q5AKR0;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Predicted GPI-anchored protein 37;
DE   Flags: Precursor;
GN   Name=PGA37; OrderedLocusNames=CAALFM_C504370CA;
GN   ORFNames=CaO19.11405, CaO19.3923;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=19249212; DOI=10.1016/j.cub.2009.01.056;
RA   Brown V., Sabina J., Johnston M.;
RT   "Specialized sugar sensing in diverse fungi.";
RL   Curr. Biol. 19:436-441(2009).
RN   [6]
RP   INDUCTION.
RX   PubMed=21592964; DOI=10.1074/jbc.m111.233569;
RA   Singh R.P., Prasad H.K., Sinha I., Agarwal N., Natarajan K.;
RT   "Cap2-HAP complex is a critical transcriptional regulator that has dual but
RT   contrasting roles in regulation of iron homeostasis in Candida albicans.";
RL   J. Biol. Chem. 286:25154-25170(2011).
RN   [7]
RP   INDUCTION.
RX   PubMed=21407800; DOI=10.1371/journal.pone.0017046;
RA   Wachtler B., Wilson D., Haedicke K., Dalle F., Hube B.;
RT   "From attachment to damage: defined genes of Candida albicans mediate
RT   adhesion, invasion and damage during interaction with oral epithelial
RT   cells.";
RL   PLoS ONE 6:E17046-E17046(2011).
CC   -!- FUNCTION: Predicted GPI-anchored protein which may have a role during
CC       host infection.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- INDUCTION: Repressed by HAP43. Down-regulated during oral epithelial
CC       infection. Up-regulated in response to galactose.
CC       {ECO:0000269|PubMed:19249212, ECO:0000269|PubMed:21407800,
CC       ECO:0000269|PubMed:21592964}.
CC   -!- SIMILARITY: Belongs to the PGA37 family. {ECO:0000305}.
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DR   EMBL; CP017627; AOW29845.1; -; Genomic_DNA.
DR   RefSeq; XP_721833.1; XM_716740.1.
DR   AlphaFoldDB; Q5AK97; -.
DR   STRING; 237561.Q5AK97; -.
DR   GeneID; 3636484; -.
DR   KEGG; cal:CAALFM_C504370CA; -.
DR   CGD; CAL0000201918; PGA37.
DR   VEuPathDB; FungiDB:C5_04370C_A; -.
DR   HOGENOM; CLU_114600_0_0_1; -.
DR   OrthoDB; 1871587at2759; -.
DR   PRO; PR:Q5AK97; -.
DR   Proteomes; UP000000559; Chromosome 5.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..185
FT                   /note="Predicted GPI-anchored protein 37"
FT                   /id="PRO_0000424949"
FT   PROPEP          186..208
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424950"
FT   REGION          33..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           185
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        173
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   208 AA;  20615 MW;  1BFEA3E182CF609C CRC64;
     MLFTQLIILL TVTSQALSVT ISDLNNIASN QVTKRLGGGS RGGSSSGSRG GSSSGSSSGS
     SSGSRGGSSS GSSSSGSRGG GSGSSSSSGS RNWGSNQYHC SGNSCGYGNY YAPSTAAAAV
     GYGTGRYTGG TQYGNNQYHC SGSTCGYGNY FAPSAAAAAA GYGSARYYAQ HHNSTSSESE
     TISGSSSLNI PSTHFYLIGF AAAYSIVL