ID   PGA39_CANAL             Reviewed;         281 AA.
AC   Q59N10; A0A1D8PSV6;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Predicted GPI-anchored protein 39;
DE   Flags: Precursor;
GN   Name=PGA39; OrderedLocusNames=CAALFM_CR04900CA;
GN   ORFNames=CaO19.13679, CaO19.6302;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=23208712; DOI=10.1128/aac.02040-12;
RA   Silva L.V., Sanguinetti M., Vandeputte P., Torelli R., Rochat B.,
RA   Sanglard D.;
RT   "Milbemycins: more than efflux inhibitors for fungal pathogens.";
RL   Antimicrob. Agents Chemother. 57:873-886(2013).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- INDUCTION: Up-regulated upon milbemycins A3 oxim derivative (A3Ox)
CC       treatment. {ECO:0000269|PubMed:23208712}.
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DR   EMBL; CP017630; AOW31223.1; -; Genomic_DNA.
DR   RefSeq; XP_711087.2; XM_705995.2.
DR   AlphaFoldDB; Q59N10; -.
DR   GeneID; 3647306; -.
DR   KEGG; cal:CAALFM_CR04900CA; -.
DR   CGD; CAL0000183239; PGA39.
DR   VEuPathDB; FungiDB:CR_04900C_A; -.
DR   HOGENOM; CLU_1030564_0_0_1; -.
DR   OMA; SSSEWIH; -.
DR   OrthoDB; 1867194at2759; -.
DR   PRO; PR:Q59N10; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..256
FT                   /note="Predicted GPI-anchored protein 39"
FT                   /id="PRO_0000424941"
FT   PROPEP          257..281
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424942"
FT   REGION          52..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..94
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           256
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        150
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        239
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        246
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        249
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        252
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   281 AA;  28771 MW;  55C8C614A54A06E4 CRC64;
     MKATTFTLLL SIATAINAAA FEDSRLKALF ARDAEISFGA TLSAEISHGF GHHHGHTADL
     SSEIGGGSSS SSVSESTVEE LSTTTTTESV SASVSASVSA SVSASVSVSS SAEETSTEAT
     ESAETTDSFE TTDSAETTDI VETTDSVDTN TTDISTTDET TEETTDATDS VETTFESVSN
     TEDLSSSSSS IITDSSESTI EETPLITDTS VPSSLSEEYS TSGSSSEWIH TTTAATSHNS
     SNSNSNHSNV SNTTTSANFA IQYGTDYGVA VVAAIVGALL I