ID   PGA41_CANAL             Reviewed;         296 AA.
AC   Q5A1B3; A0A1D8PMK7; Q5A1H1;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Probable cell wall protein PGA41;
DE   AltName: Full=Predicted GPI-anchored protein 41;
DE   Flags: Precursor;
GN   Name=PGA41; OrderedLocusNames=CAALFM_C406310CA;
GN   ORFNames=CaO19.10424, CaO19.2906;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=23208712; DOI=10.1128/aac.02040-12;
RA   Silva L.V., Sanguinetti M., Vandeputte P., Torelli R., Rochat B.,
RA   Sanglard D.;
RT   "Milbemycins: more than efflux inhibitors for fungal pathogens.";
RL   Antimicrob. Agents Chemother. 57:873-886(2013).
CC   -!- FUNCTION: Probable GPI-anchored cell wall protein that may be involved
CC       in cell wall organization, hyphal growth, as well as in virulence.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}. Membrane
CC       {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
CC   -!- INDUCTION: Up-regulated upon milbemycin A3 oxim derivative (A3Ox)
CC       treatment. {ECO:0000269|PubMed:23208712}.
CC   -!- PTM: The GPI-anchor is attached to the protein in the endoplasmic
CC       reticulum and serves to target the protein to the cell surface. There,
CC       the glucosamine-inositol phospholipid moiety is cleaved off and the
CC       GPI-modified mannoprotein is covalently attached via its lipidless GPI
CC       glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IHD1 family. {ECO:0000305}.
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DR   EMBL; CP017626; AOW29357.1; -; Genomic_DNA.
DR   RefSeq; XP_715561.2; XM_710468.2.
DR   AlphaFoldDB; Q5A1B3; -.
DR   STRING; 237561.Q5A1B3; -.
DR   GeneID; 3642800; -.
DR   KEGG; cal:CAALFM_C406310CA; -.
DR   CGD; CAL0000197357; PGA41.
DR   VEuPathDB; FungiDB:C4_06310C_A; -.
DR   HOGENOM; CLU_940073_0_0_1; -.
DR   OrthoDB; 1820708at2759; -.
DR   PRO; PR:Q5A1B3; -.
DR   Proteomes; UP000000559; Chromosome 4.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell wall; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..275
FT                   /note="Probable cell wall protein PGA41"
FT                   /id="PRO_0000424739"
FT   PROPEP          276..296
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424740"
FT   REGION          146..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..236
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..276
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           275
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        229
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        268
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   296 AA;  30408 MW;  BBA31C2B217B0D49 CRC64;
     MKFTIVLFTL ISVTVAAAAT TTTTAAANRI QNKAYAYYYC NSYCTQAVND ENSCGYYDTD
     VSNQEYYACL CTKSSYYNNL RSCDCFTKVV YYYSTSICSR ANVGTYVGGR TSTTWGVSAT
     KYRSSTSTSS LTRKSSSIGA SPSIAIASST KESSSTESSS SLEQSSSAGQ SSSTEQSPST
     EVSSSSSIEE SSSNQDISST DSITTISSDS STGNTDSPTQ GGGGNSGNNG SNGDGGNDAS
     GGGGVVNENE QASSPPSSQS STNSNQPNSS QTAPGAANYL SSVSVGTLMI LVLGLI