PGA42_CANAL
ID PGA42_CANAL Reviewed; 227 AA.
AC Q5A1B2; A0A1D8PMI8; Q5A1H0;
DT 11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Probable cell wall protein PGA42;
DE AltName: Full=Predicted GPI-anchored protein 42;
DE Flags: Precursor;
GN Name=PGA42; OrderedLocusNames=CAALFM_C406300CA;
GN ORFNames=CaO19.10425, CaO19.2907;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP PREDICTION OF GPI-ANCHOR.
RX PubMed=12845604; DOI=10.1002/yea.1007;
RA De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT "Genome-wide identification of fungal GPI proteins.";
RL Yeast 20:781-796(2003).
RN [5]
RP INDUCTION.
RX PubMed=23208712; DOI=10.1128/aac.02040-12;
RA Silva L.V., Sanguinetti M., Vandeputte P., Torelli R., Rochat B.,
RA Sanglard D.;
RT "Milbemycins: more than efflux inhibitors for fungal pathogens.";
RL Antimicrob. Agents Chemother. 57:873-886(2013).
CC -!- FUNCTION: Probable GPI-anchored cell wall protein that may be involved
CC in cell wall organization, hyphal growth, as well as in virulence.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}. Membrane
CC {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
CC -!- INDUCTION: Up-regulated upon milbemycin A3 oxim derivative (A3Ox)
CC treatment. {ECO:0000269|PubMed:23208712}.
CC -!- PTM: The GPI-anchor is attached to the protein in the endoplasmic
CC reticulum and serves to target the protein to the cell surface. There,
CC the glucosamine-inositol phospholipid moiety is cleaved off and the
CC GPI-modified mannoprotein is covalently attached via its lipidless GPI
CC glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IHD1 family. {ECO:0000305}.
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DR EMBL; CP017626; AOW29356.1; -; Genomic_DNA.
DR RefSeq; XP_715562.2; XM_710469.2.
DR AlphaFoldDB; Q5A1B2; -.
DR STRING; 237561.Q5A1B2; -.
DR GeneID; 3642801; -.
DR KEGG; cal:CAALFM_C406300CA; -.
DR CGD; CAL0000192200; PGA42.
DR VEuPathDB; FungiDB:C4_06300C_A; -.
DR HOGENOM; CLU_1189771_0_0_1; -.
DR PRO; PR:Q5A1B2; -.
DR Proteomes; UP000000559; Chromosome 4.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cell wall; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Secreted; Signal; Virulence.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..200
FT /note="Probable cell wall protein PGA42"
FT /id="PRO_0000424741"
FT PROPEP 201..227
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000424742"
FT LIPID 200
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 227 AA; 25141 MW; D9087AD86DEAB5B2 CRC64;
MKFIILLFAL IHITVAANRA LIIDYSYYGC NLDCYIASNQ ENTCGAHDDD VSDQQYHACL
CMNYDYFTNL MNCNCFDSNV YYVSSSICSM ATASSEFETY DGAPSTMDVS TTDYSSSTED
ISFTEDVSFT EDDSFTEYSS FTKYSSFTKY SSSVSSFTKV IWSTLETSSI KGIAATTSSY
FTNAQTTSGT ANDSSISKPS GSQIFVLCVI SVVGFIFFFL FFLSLFV