ID   PGA44_CANAL             Reviewed;         307 AA.
AC   Q5AJK6; A0A1D8PJ58;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Predicted GPI-anchored protein 44;
DE   Flags: Precursor;
GN   Name=PGA44; OrderedLocusNames=CAALFM_C301370CA; ORFNames=CaO19.1714;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=23208712; DOI=10.1128/aac.02040-12;
RA   Silva L.V., Sanguinetti M., Vandeputte P., Torelli R., Rochat B.,
RA   Sanglard D.;
RT   "Milbemycins: more than efflux inhibitors for fungal pathogens.";
RL   Antimicrob. Agents Chemother. 57:873-886(2013).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- INDUCTION: Up-regulated upon milbemycins A3 oxim derivative (A3Ox)
CC       treatment. {ECO:0000269|PubMed:23208712}.
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DR   EMBL; CP017625; AOW28180.1; -; Genomic_DNA.
DR   RefSeq; XP_721785.2; XM_716692.2.
DR   AlphaFoldDB; Q5AJK6; -.
DR   GeneID; 3636647; -.
DR   KEGG; cal:CAALFM_C301370CA; -.
DR   CGD; CAL0000176642; PGA44.
DR   VEuPathDB; FungiDB:C3_01370C_A; -.
DR   HOGENOM; CLU_915257_0_0_1; -.
DR   OrthoDB; 1744853at2759; -.
DR   Proteomes; UP000000559; Chromosome 3.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..286
FT                   /note="Predicted GPI-anchored protein 44"
FT                   /id="PRO_0000429946"
FT   PROPEP          287..307
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000429947"
FT   REGION          232..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           286
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        146
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        217
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   307 AA;  32317 MW;  B98A351D42DB1A7B CRC64;
     MLSTNNLLIL LIFSFLITNV KSDLGGPCFS MSTMEGFACG LGVHKNIQII TDCLCYIPGY
     WEQLDGCDKL VRGPHHTPID GAEICSRASE YAANPAGFTG ETDYYESSTT VMHVVMLDFP
     TYSPGVTNFL DSSSNDLTTT NTDEINSSIT TDEVIPSSSS SYIEIPSETL MESSVSTQPS
     TIETSETSHA TSLEVSSIIT GVSSEPLTIV SESGGLNSTE IASTPVVITS PTPQPLLETP
     SQESSAPNID STTPTTIDNT VVDGTTTNDA TSVASSTSDV AYVYIGGAMG YPSISVALGL
     VFIAYLV