PGA46_CANAL
ID PGA46_CANAL Reviewed; 340 AA.
AC Q59Y11; A0A1D8PI99;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Predicted GPI-anchored protein 46;
DE Flags: Precursor;
GN Name=PGA46; OrderedLocusNames=CAALFM_C208430CA;
GN ORFNames=CaO19.11120, CaO19.3638;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP PREDICTION OF GPI-ANCHOR.
RX PubMed=12845604; DOI=10.1002/yea.1007;
RA De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT "Genome-wide identification of fungal GPI proteins.";
RL Yeast 20:781-796(2003).
RN [5]
RP INDUCTION.
RX PubMed=23208712; DOI=10.1128/aac.02040-12;
RA Silva L.V., Sanguinetti M., Vandeputte P., Torelli R., Rochat B.,
RA Sanglard D.;
RT "Milbemycins: more than efflux inhibitors for fungal pathogens.";
RL Antimicrob. Agents Chemother. 57:873-886(2013).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=21622905; DOI=10.1128/ec.05011-11;
RA Sorgo A.G., Heilmann C.J., Dekker H.L., Bekker M., Brul S., de Koster C.G.,
RA de Koning L.J., Klis F.M.;
RT "Effects of fluconazole on the secretome, the wall proteome, and wall
RT integrity of the clinical fungus Candida albicans.";
RL Eukaryot. Cell 10:1071-1081(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}. Secreted {ECO:0000269|PubMed:21622905}.
CC -!- INDUCTION: Up-regulated upon milbemycins A3 oxim derivative (A3Ox)
CC treatment. {ECO:0000269|PubMed:23208712}.
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DR EMBL; CP017624; AOW27832.1; -; Genomic_DNA.
DR RefSeq; XP_714479.2; XM_709386.2.
DR AlphaFoldDB; Q59Y11; -.
DR SMR; Q59Y11; -.
DR GeneID; 3643896; -.
DR KEGG; cal:CAALFM_C208430CA; -.
DR CGD; CAL0000193043; PGA46.
DR VEuPathDB; FungiDB:C2_08430C_A; -.
DR eggNOG; ENOG502RQ6I; Eukaryota.
DR HOGENOM; CLU_882773_0_0_1; -.
DR InParanoid; Q59Y11; -.
DR OrthoDB; 1442141at2759; -.
DR PRO; PR:Q59Y11; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..314
FT /note="Predicted GPI-anchored protein 46"
FT /id="PRO_0000429950"
FT PROPEP 315..340
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000429951"
FT REGION 99..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 314
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 270
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 340 AA; 38706 MW; 6E383F33625D2B86 CRC64;
MKILLIYSMT PKLVIWFTLF VLCLQMGDTF DISINNEEID NPGLIIKSKF KKYLPELQEN
LEIPITEKQQ SIKESFIPRR INYPHYGLRS RFRKDIAISE TTTTTTQESE TSIATNGDSF
DSDNGENKSD SSDDESSNNE GNDKSDATFK SLSSSSPTVV HSRRSWIKDF LIFKEQKVST
MSSSSSSSSG SLRDKSKLKQ ENKQLQSRIK NYDDTVSDPR DLKRWVRLIA DEGKNEFGKK
HSSKNYIQKN EIELDIEEFI HYLVEEQGFN SSDLEFLRLK NLDYGLGEIE KELNKLKEAK
GSPKVISIGG EDENSAPLLW IKISKPTVCL VIALTFLLLG
