ID   PGA48_CANAL             Reviewed;         108 AA.
AC   Q59L96; A0A1D8PPC0;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Cell wall protein PGA48;
DE   AltName: Full=Predicted GPI-anchored protein 48;
DE   Flags: Precursor;
GN   Name=PGA48; Synonyms=SPI1; OrderedLocusNames=CAALFM_C600160WA;
GN   ORFNames=CaO19.6321;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=15387822; DOI=10.1111/j.1365-2958.2004.04214.x;
RA   Lan C.Y., Rodarte G., Murillo L.A., Jones T., Davis R.W., Dungan J.,
RA   Newport G., Agabian N.;
RT   "Regulatory networks affected by iron availability in Candida albicans.";
RL   Mol. Microbiol. 53:1451-1469(2004).
CC   -!- FUNCTION: Cell wall protein that plays a role in adaptation and
CC       resistance to cell wall stress. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}. Membrane
CC       {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=Covalently-
CC       linked GPI-modified cell wall protein (GPI-CWP). {ECO:0000250}.
CC   -!- INDUCTION: Expression is induced in high iron conditions.
CC       {ECO:0000269|PubMed:15387822}.
CC   -!- PTM: The GPI-anchor is attached to the protein in the endoplasmic
CC       reticulum and serves to target the protein to the cell surface. There,
CC       the glucosamine-inositol phospholipid moiety is cleaved off and the
CC       GPI-modified mannoprotein is covalently attached via its lipidless GPI
CC       glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SED1 family. {ECO:0000305}.
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DR   EMBL; CP017628; AOW29966.1; -; Genomic_DNA.
DR   RefSeq; XP_710492.2; XM_705400.2.
DR   AlphaFoldDB; Q59L96; -.
DR   GeneID; 3647905; -.
DR   KEGG; cal:CAALFM_C600160WA; -.
DR   CGD; CAL0000178188; PGA48.
DR   VEuPathDB; FungiDB:C6_00160W_A; -.
DR   HOGENOM; CLU_119130_0_0_1; -.
DR   InParanoid; Q59L96; -.
DR   OrthoDB; 1866111at2759; -.
DR   Proteomes; UP000000559; Chromosome 6.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell wall; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..84
FT                   /note="Cell wall protein PGA48"
FT                   /id="PRO_0000429944"
FT   PROPEP          85..108
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000429945"
FT   LIPID           84
FT                   /note="GPI-anchor amidated asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   108 AA;  11559 MW;  5ECB7C1DC258394D CRC64;
     MFKFVIYLFT FIAFANANYT TWSLVTDYTT YCPQSTEITV NNSIITITGP TTLTITGECT
     LDYVATVEAA PSSIPSNVTV IESNGASKLN LRSLAGAGLV AAIFIAFI