PGA52_CANAL
ID PGA52_CANAL Reviewed; 384 AA.
AC Q59L72; A0A1D8PG07; Q59L52;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=GPI-anchored protein 52;
DE Flags: Precursor;
GN Name=PGA52; OrderedLocusNames=CAALFM_C200100CA;
GN ORFNames=CaO19.1911, CaO19.9467;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP PREDICTION OF GPI-ANCHOR.
RX PubMed=12845604; DOI=10.1002/yea.1007;
RA De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT "Genome-wide identification of fungal GPI proteins.";
RL Yeast 20:781-796(2003).
RN [5]
RP INDUCTION.
RX PubMed=15820985; DOI=10.1093/jac/dki088;
RA Copping V.M.S., Barelle C.J., Hube B., Gow N.A.R., Brown A.J.P., Odds F.C.;
RT "Exposure of Candida albicans to antifungal agents affects expression of
RT SAP2 and SAP9 secreted proteinase genes.";
RL J. Antimicrob. Chemother. 55:645-654(2005).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=19824013; DOI=10.1002/pmic.200800988;
RA Cabezon V., Llama-Palacios A., Nombela C., Monteoliva L., Gil C.;
RT "Analysis of Candida albicans plasma membrane proteome.";
RL Proteomics 9:4770-4786(2009).
RN [7]
RP INDUCTION.
RX PubMed=21592964; DOI=10.1074/jbc.m111.233569;
RA Singh R.P., Prasad H.K., Sinha I., Agarwal N., Natarajan K.;
RT "Cap2-HAP complex is a critical transcriptional regulator that has dual but
RT contrasting roles in regulation of iron homeostasis in Candida albicans.";
RL J. Biol. Chem. 286:25154-25170(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19824013};
CC Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19824013}.
CC -!- INDUCTION: Expression is induced by fluconazole and repressed by HAP43.
CC {ECO:0000269|PubMed:15820985, ECO:0000269|PubMed:21592964}.
CC -!- SIMILARITY: Belongs to the PGA52 family. {ECO:0000305}.
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DR EMBL; CP017624; AOW27065.1; -; Genomic_DNA.
DR RefSeq; XP_710476.2; XM_705384.2.
DR AlphaFoldDB; Q59L72; -.
DR STRING; 237561.Q59L72; -.
DR GeneID; 3647908; -.
DR KEGG; cal:CAALFM_C200100CA; -.
DR CGD; CAL0000178744; PGA52.
DR VEuPathDB; FungiDB:C2_00100C_A; -.
DR eggNOG; ENOG502QSTV; Eukaryota.
DR HOGENOM; CLU_030276_4_0_1; -.
DR OMA; STIHDYQ; -.
DR OrthoDB; 989394at2759; -.
DR PRO; PR:Q59L72; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009277; C:fungal-type cell wall; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018805; YJL171C/Tos1_C.
DR InterPro; IPR018807; YJL171C/Tos1_N.
DR Pfam; PF10287; DUF2401; 1.
DR Pfam; PF10290; DUF2403; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..361
FT /note="GPI-anchored protein 52"
FT /id="PRO_0000429964"
FT PROPEP 362..384
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000429965"
FT LIPID 361
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 244
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 262
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 318
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 384 AA; 41476 MW; 9E6E5973A887E994 CRC64;
MLFSSLLVST LVSVATAANQ EVEAIQFSNL GFSGTYNQVE KLSNIYKDSC SCEVNKTPVS
FSGTNAPLNE EVSVHFRGPL VLNKFASYVS DGFKYGDDSS GDWKRLSYYE GSSGTSENVT
FLTSAGKNSS CLGIGLTYAG TDGISKADSS TVLAKNTLIN SNDEFVIFSN ISCGKSGYNN
DCGVYRSDIP AYHGFYGTTK MFLFEFQMPN ETHTSTDISN YNMPAIWLLN AHIPRTAQYS
MNVNCSCWRS GCGEFDIFEV MNSTEYLHMY STIHDYQGSD DIQTGMAAPA YIERDLTGTM
SGGVAFDSSG NAVVWVSNST SFDSTIQASS VNSWVKQAGA DVATTLATVT GQSATTTSKK
SGGVSYQPSF ITNLLMTVLT LWVI
