PGA54_CANAL
ID PGA54_CANAL Reviewed; 342 AA.
AC Q5AFC2; A0A1D8PLQ5;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 2.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Predicted GPI-anchored protein 54;
DE Flags: Precursor;
GN Name=PGA54; OrderedLocusNames=CAALFM_C403070WA;
GN ORFNames=CaO19.10200, CaO19.2685;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP PREDICTION OF GPI-ANCHOR.
RX PubMed=12845604; DOI=10.1002/yea.1007;
RA De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT "Genome-wide identification of fungal GPI proteins.";
RL Yeast 20:781-796(2003).
RN [5]
RP INDUCTION.
RX PubMed=15814841; DOI=10.1091/mbc.e05-01-0071;
RA Garcia-Sanchez S., Mavor A.L., Russell C.L., Argimon S., Dennison P.,
RA Enjalbert B., Brown A.J.;
RT "Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the
RT fungal pathogen, Candida albicans.";
RL Mol. Biol. Cell 16:2913-2925(2005).
RN [6]
RP INDUCTION.
RX PubMed=16339080; DOI=10.1091/mbc.e05-06-0501;
RA Enjalbert B., Smith D.A., Cornell M.J., Alam I., Nicholls S., Brown A.J.P.,
RA Quinn J.;
RT "Role of the Hog1 stress-activated protein kinase in the global
RT transcriptional response to stress in the fungal pathogen Candida
RT albicans.";
RL Mol. Biol. Cell 17:1018-1032(2006).
RN [7]
RP INDUCTION.
RX PubMed=17645752; DOI=10.1111/j.1462-5822.2007.01009.x;
RA Zakikhany K., Naglik J.R., Schmidt-Westhausen A., Holland G., Schaller M.,
RA Hube B.;
RT "In vivo transcript profiling of Candida albicans identifies a gene
RT essential for interepithelial dissemination.";
RL Cell. Microbiol. 9:2938-2954(2007).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC -!- INDUCTION: Expression is induced during infection of reconstituted
CC human oral epithelium. Expression is repressed by HOG1 and regulated by
CC TEC1, EGF1, NTD80, ROB1, BRG1, and SSN6. {ECO:0000269|PubMed:15814841,
CC ECO:0000269|PubMed:16339080, ECO:0000269|PubMed:17645752}.
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DR EMBL; CP017626; AOW29070.1; -; Genomic_DNA.
DR RefSeq; XP_720438.2; XM_715345.2.
DR AlphaFoldDB; Q5AFC2; -.
DR BioGRID; 1221023; 1.
DR STRING; 237561.Q5AFC2; -.
DR GeneID; 3637929; -.
DR KEGG; cal:CAALFM_C403070WA; -.
DR CGD; CAL0000192137; PGA54.
DR VEuPathDB; FungiDB:C4_03070W_A; -.
DR HOGENOM; CLU_792252_0_0_1; -.
DR InParanoid; Q5AFC2; -.
DR OMA; YCVPTTV; -.
DR PRO; PR:Q5AFC2; -.
DR Proteomes; UP000000559; Chromosome 4.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..314
FT /note="Predicted GPI-anchored protein 54"
FT /id="PRO_0000429956"
FT PROPEP 315..342
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000429957"
FT LIPID 314
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 326
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 342 AA; 36033 MW; 6D4C53A892A6CBEC CRC64;
MRANYLLLLA ATAVQAAPFI KRYENTTAPA SQLSTSLADG STTILGSSSS SVEEDETITS
TIVQYVTVTS SDTTYVSATN TLTTTLTTKP TPVITTEAED DEEDNETITS TILQYVTVTS
SDTTYVSATN TLTTTLTTKA AEATESEEEE NETITSTILQ YVTVTSSDTT YVSATNTITS
VLTTKAAVST NDVSENAKAA TTEDDGETTT STITSIVTIT DANGNTEVLT EVAAETSGAE
DASYCVPTTV TVTVTAEQTS EVVSTIVHTT QVPLTAEFTL DDTTTTLTSW VDLTSTDLVT
ITSTSSVYDS YSTGASQSHP ISSYSNYTIS DYAPPISSYY SL
