PGA55_CANAL
ID PGA55_CANAL Reviewed; 1404 AA.
AC Q59SG9; A0A1D8PIB4; Q59SD7;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Probable GPI-anchored adhesin-like protein PGA55;
DE AltName: Full=Predicted GPI-anchored protein 55;
DE Flags: Precursor;
GN Name=PGA55; OrderedLocusNames=CAALFM_C208980CA;
GN ORFNames=CaO19.207, CaO19.7838;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP PREDICTION OF GPI-ANCHOR.
RX PubMed=12845604; DOI=10.1002/yea.1007;
RA De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT "Genome-wide identification of fungal GPI proteins.";
RL Yeast 20:781-796(2003).
RN [5]
RP INDUCTION.
RX PubMed=15814840; DOI=10.1091/mbc.e05-01-0073;
RA Kadosh D., Johnson A.D.;
RT "Induction of the Candida albicans filamentous growth program by relief of
RT transcriptional repression: a genome-wide analysis.";
RL Mol. Biol. Cell 16:2903-2912(2005).
RN [6]
RP SUBCELLULAR LOCATION, AND MRNA TRANSPORT.
RX PubMed=19779551; DOI=10.1371/journal.pgen.1000664;
RA Elson S.L., Noble S.M., Solis N.V., Filler S.G., Johnson A.D.;
RT "An RNA transport system in Candida albicans regulates hyphal morphology
RT and invasive growth.";
RL PLoS Genet. 5:E1000664-E1000664(2009).
RN [7]
RP FUNCTION.
RX PubMed=21496229; DOI=10.1186/1471-2164-12-192;
RA Chaudhuri R., Ansari F.A., Raghunandanan M.V., Ramachandran S.;
RT "FungalRV: adhesin prediction and immunoinformatics portal for human fungal
RT pathogens.";
RL BMC Genomics 12:192-192(2011).
RN [8]
RP INDUCTION.
RX PubMed=23613980; DOI=10.1371/journal.pone.0061940;
RA Palige K., Linde J., Martin R., Bottcher B., Citiulo F., Sullivan D.J.,
RA Weber J., Staib C., Rupp S., Hube B., Morschhauser J., Staib P.;
RT "Global transcriptome sequencing identifies chlamydospore specific markers
RT in Candida albicans and Candida dubliniensis.";
RL PLoS ONE 8:E61940-E61940(2013).
CC -!- FUNCTION: Predicted GPI-ancored adhesin-like protein which may be
CC involved in filamentous growth and chlamydospore formation.
CC {ECO:0000269|PubMed:21496229}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}. Note=Accumulates in the bud of yeast cells and in
CC the distal end of the germ tube and hyphal tip cell.
CC {ECO:0000269|PubMed:19779551}.
CC -!- INDUCTION: Induced during chlamydospore formation and filamentous
CC growth. Expression is regulated by the NRG1 and TUP1 transcription
CC factors. {ECO:0000269|PubMed:15814840, ECO:0000269|PubMed:23613980}.
CC -!- MISCELLANEOUS: The PGA55 mRNA is transported by SHE3 to bud in yeast
CC cells, as well as to the hyphal tips during filamentous growth.
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DR EMBL; CP017624; AOW27886.1; -; Genomic_DNA.
DR RefSeq; XP_712591.2; XM_707498.2.
DR AlphaFoldDB; Q59SG9; -.
DR STRING; 237561.Q59SG9; -.
DR GeneID; 3645784; -.
DR KEGG; cal:CAALFM_C208980CA; -.
DR CGD; CAL0000189083; PGA55.
DR VEuPathDB; FungiDB:C2_08980C_A; -.
DR HOGENOM; CLU_006027_0_0_1; -.
DR OrthoDB; 1681856at2759; -.
DR PRO; PR:Q59SG9; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Repeat; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..1382
FT /note="Probable GPI-anchored adhesin-like protein PGA55"
FT /id="PRO_0000424917"
FT PROPEP 1383..1404
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000424918"
FT REPEAT 104..109
FT /note="1-1"
FT REPEAT 136..141
FT /note="1-2"
FT REPEAT 156..161
FT /note="1-3"
FT REPEAT 162..167
FT /note="1-4"
FT REPEAT 183..188
FT /note="1-5"
FT REPEAT 196..201
FT /note="1-6"
FT REPEAT 203..208
FT /note="1-7"
FT REPEAT 209..214
FT /note="1-8"
FT REPEAT 216..221
FT /note="1-9"
FT REPEAT 222..227
FT /note="1-10"
FT REPEAT 228..233
FT /note="1-11"
FT REPEAT 234..239
FT /note="1-12"
FT REPEAT 247..252
FT /note="1-13"
FT REPEAT 253..258
FT /note="1-14"
FT REPEAT 261..266
FT /note="1-15"
FT REPEAT 267..272
FT /note="1-16"
FT REPEAT 274..279
FT /note="1-17"
FT REPEAT 280..285
FT /note="1-18"
FT REPEAT 286..291
FT /note="1-19"
FT REPEAT 292..297
FT /note="1-20"
FT REPEAT 298..303
FT /note="1-21"
FT REPEAT 304..309
FT /note="1-22"
FT REPEAT 317..322
FT /note="1-23"
FT REPEAT 324..329
FT /note="1-24"
FT REPEAT 330..335
FT /note="1-25"
FT REPEAT 336..341
FT /note="1-26"
FT REPEAT 343..348
FT /note="1-27"
FT REPEAT 349..354
FT /note="1-28"
FT REPEAT 355..360
FT /note="1-29"
FT REPEAT 361..366
FT /note="1-30"
FT REPEAT 374..379
FT /note="1-31"
FT REPEAT 380..385
FT /note="1-32"
FT REPEAT 388..393
FT /note="1-33"
FT REPEAT 394..399
FT /note="1-34"
FT REPEAT 401..406
FT /note="1-35"
FT REPEAT 407..412
FT /note="1-36"
FT REPEAT 413..418
FT /note="1-37"
FT REPEAT 419..424
FT /note="1-38"
FT REPEAT 425..430
FT /note="1-39"
FT REPEAT 431..436
FT /note="1-40"
FT REPEAT 444..449
FT /note="1-41"
FT REPEAT 450..455
FT /note="1-42"
FT REPEAT 457..462
FT /note="1-43"
FT REPEAT 463..468
FT /note="1-44"
FT REPEAT 469..474
FT /note="1-45"
FT REPEAT 475..480
FT /note="1-46"
FT REPEAT 488..493
FT /note="1-47"
FT REPEAT 494..500
FT /note="1-48"
FT REPEAT 502..507
FT /note="1-49"
FT REPEAT 508..513
FT /note="1-50"
FT REPEAT 515..520
FT /note="1-51"
FT REPEAT 521..526
FT /note="1-52"
FT REPEAT 527..532
FT /note="1-53"
FT REPEAT 533..538
FT /note="1-54"
FT REPEAT 546..551
FT /note="1-55"
FT REPEAT 552..557
FT /note="1-56"
FT REPEAT 560..565
FT /note="1-57"
FT REPEAT 566..571
FT /note="1-58"
FT REPEAT 573..578
FT /note="1-59"
FT REPEAT 579..584
FT /note="1-60"
FT REPEAT 585..590
FT /note="1-61"
FT REPEAT 591..596
FT /note="1-62"
FT REPEAT 604..609
FT /note="1-63"
FT REPEAT 611..616
FT /note="1-64"
FT REPEAT 617..622
FT /note="1-65"
FT REPEAT 623..628
FT /note="1-66"
FT REPEAT 629..634
FT /note="1-67"
FT REPEAT 635..640
FT /note="1-68"
FT REPEAT 641..646
FT /note="1-69"
FT REPEAT 654..659
FT /note="1-70"
FT REPEAT 660..665
FT /note="1-71"
FT REPEAT 668..673
FT /note="1-72"
FT REPEAT 674..679
FT /note="1-73"
FT REPEAT 681..686
FT /note="1-74"
FT REPEAT 687..692
FT /note="1-75"
FT REPEAT 693..698
FT /note="1-76"
FT REPEAT 699..704
FT /note="1-77"
FT REPEAT 712..717
FT /note="1-78"
FT REPEAT 719..724
FT /note="1-79"
FT REPEAT 725..730
FT /note="1-80"
FT REPEAT 731..736
FT /note="1-81"
FT REPEAT 737..742
FT /note="1-82"
FT REPEAT 743..748
FT /note="1-83"
FT REPEAT 749..754
FT /note="1-84"
FT REPEAT 771..776
FT /note="1-85"
FT REPEAT 777..782
FT /note="1-86"
FT REPEAT 797..802
FT /note="1-87"
FT REPEAT 824..829
FT /note="1-88"
FT REGION 104..541
FT /note="88 X 6 AA approximate tandem repeats"
FT REGION 113..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 1382
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 817
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 994
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1074
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1404 AA; 142167 MW; D8693E3089E9F04A CRC64;
MVLLCKYKVS WVFVLSVAGS SLIRDFLFGQ DDSLSIEKRT NEYTTPEYGG TSHCNGGDKN
CYPQCFDHRG QPKKDKCCFD KHNKVLYPYP CTSSSSSSSS SSTVSSSSSE VISSSSEEAS
SSEITSSSEI SSSSEVSSSS EVLSSSEIIS SSSEVVSSSS KVSSSSEATS SSSEIISSSS
EVVSSSSQVT SSSEVVSSSS EVVSSSSEVS SSSEVVSSSS EVSSSSEVSS SSEVSSSSQV
TSSSEIVSSS SEVSSSSSEV VSSSSEVSSS SEVVSSSSEV SSSSEVSSSS EVSSSSEVSS
SSEVSSSSQV ISSSEVVSSS SEVVSSSSEV SSSSEVSSSS EVVSSSSEVS SSSEVSSSSE
VSSSSQVTSS SEIVSSSSEV SSSSSEVVSS SSEVSSSSEV VSSSSEVSSS SEVSSSSEVS
SSSEVSSSSE VSSSSQVTSS SEVVSSSSEV SSSSEVVSSS SEVSSSSEVS SSSEVSSSSQ
VTSSSEIVSS SSEVSSSSSE VVSSSSEVSS SSEVVSSSSE VSSSSEVSSS SEVSSSSQVT
SSSEIVSSSS EVSSSSSEVV SSSSEVSSSS EVVSSSSEVS SSSEVSSSSE VSSSSQVTSS
SEVVSSSSEV VSSSSEVSSS SEVSSSSEVS SSSEVSSSSE VSSSSQVTSS SEIVSSSSEV
SSSSSEVVSS SSEVSSSSEV VSSSSEVSSS SEVSSSSEVS SSSQVTSSSE VVSSSSEVVS
SSSEVSSSSE VSSSSEVSSS SEVSSSSEVS SSSEVTSSSS EIISSSSSSE VTSSSEVSSS
SQATSSSSEI ISSSSKVSSS SEITSSSECI SSTSEVNSSS SEVVSSSSAS SEVVSSSTEC
ISSSSEAISS SSQVTSSSTE CISSSSEVIS SSEVTSCSSE VVSSSETCIS SKEMSSSEQI
SSSESTSSCS EFVSKSSEHS SLSSESCPSE ETSTVSETSS ETVTCKHHGC SKTKTHHSTP
TKCVTKTIET SVYVTTCPDK SITTETAVVI VVTNESTATT YTEIIKTTVI EGNTLTTNIP
IKHVETETAE IIEYTTICPT TLPNGHKTTV IAGIAVGTNG QGQKVTKTVP LEYNESTLAN
GHVTRVASGI VKATGENGEE ITKTIPIEYR KTTERIEFIT VCPTTLANGQ VIETTAGIVI
TTNKQGEKVT KPVPLEFTST IEFSHHLTTH PVTLPNGQIT VTTEGVIITR KGEQQFTKTV
EVGNLPSKPI EVVQKISVVP KTLPNSQVTS ETVAILVTVG EELQPITKTI PIGTSAQETE
PSFASYSEIV FTTCSEGGCN TYTTNVEVIG NKVITKQSGK PIVEEQTTNG IEHQSDKVYY
TVVSGETKTI QTPGSIVSTS PAAIPVVTSK GSPNIVGSSV VAGSSVTTSE VSTSTAGVLQ
GNAASRQSFN YKFIVGLILA YIIA
