ID   PGA57_CANAL             Reviewed;         214 AA.
AC   Q5AMF7; A0A1D8PL93; Q5AMW3;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Predicted GPI-anchored protein 57;
DE   Flags: Precursor;
GN   Name=PGA57; OrderedLocusNames=CAALFM_C401000CA;
GN   ORFNames=CaO19.12158, CaO19.4689;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=12456000; DOI=10.1128/ec.1.4.514-525.2002;
RA   Monteoliva L., Matas M.L., Gil C., Nombela C., Pla J.;
RT   "Large-scale identification of putative exported proteins in Candida
RT   albicans by genetic selection.";
RL   Eukaryot. Cell 1:514-525(2002).
RN   [5]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [6]
RP   INDUCTION.
RX   PubMed=21592964; DOI=10.1074/jbc.m111.233569;
RA   Singh R.P., Prasad H.K., Sinha I., Agarwal N., Natarajan K.;
RT   "Cap2-HAP complex is a critical transcriptional regulator that has dual but
RT   contrasting roles in regulation of iron homeostasis in Candida albicans.";
RL   J. Biol. Chem. 286:25154-25170(2011).
CC   -!- FUNCTION: Predicted GPI-anchored protein which may have a role during
CC       host infection. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12456000}. Cell
CC       membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
CC   -!- INDUCTION: Induced by HAP43. {ECO:0000269|PubMed:21592964}.
CC   -!- SIMILARITY: Belongs to the PGA37 family. {ECO:0000305}.
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DR   EMBL; CP017626; AOW28889.1; -; Genomic_DNA.
DR   RefSeq; XP_722756.1; XM_717663.1.
DR   AlphaFoldDB; Q5AMF7; -.
DR   GeneID; 3635608; -.
DR   KEGG; cal:CAALFM_C401000CA; -.
DR   CGD; CAL0000175219; PGA57.
DR   VEuPathDB; FungiDB:C4_01000C_A; -.
DR   HOGENOM; CLU_114600_0_0_1; -.
DR   OMA; STHFYVI; -.
DR   OrthoDB; 1847416at2759; -.
DR   PRO; PR:Q5AMF7; -.
DR   Proteomes; UP000000559; Chromosome 4.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..191
FT                   /note="Predicted GPI-anchored protein 57"
FT                   /id="PRO_0000424951"
FT   PROPEP          192..214
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424952"
FT   REGION          36..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           191
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        182
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   214 AA;  21206 MW;  8DC137D89BBB93EC CRC64;
     MLFTQLIILF TFISQIICVS ISDLNNIALI QFTKRRGSSG HSSGGGHSSS GSHSSGGGHS
     SSGSSSSGSK GGGSSSGSSS GSSSGTKGGG SSSGSSSGSR NWGSNQYHCT GNSCGYGNYF
     APSAAAAAVG YGTGRYTGGT KYGNNQYHCS GSTCGYGNYY APTAASAAAG YGSARYAGQH
     NNSTSTKTSF GVSLNIPSTH FYVIGLAAAY SIVL