ID   PGA58_CANAL             Reviewed;         240 AA.
AC   Q5AG46; A0A1D8PNL2;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Predicted GPI-anchored protein 58;
DE   Flags: Precursor;
GN   Name=PGA58; OrderedLocusNames=CAALFM_C503050CA;
GN   ORFNames=CaO19.11809, CaO19.4334;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=23208712; DOI=10.1128/aac.02040-12;
RA   Silva L.V., Sanguinetti M., Vandeputte P., Torelli R., Rochat B.,
RA   Sanglard D.;
RT   "Milbemycins: more than efflux inhibitors for fungal pathogens.";
RL   Antimicrob. Agents Chemother. 57:873-886(2013).
RN   [6]
RP   INDUCTION.
RX   PubMed=18342603; DOI=10.1016/j.molcel.2008.02.006;
RA   Hogues H., Lavoie H., Sellam A., Mangos M., Roemer T., Purisima E.,
RA   Nantel A., Whiteway M.;
RT   "Transcription factor substitution during the evolution of fungal ribosome
RT   regulation.";
RL   Mol. Cell 29:552-562(2008).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- INDUCTION: Up-regulated by TBF1 and upon milbemycins A3 oxim derivative
CC       (A3Ox) treatment. {ECO:0000269|PubMed:18342603,
CC       ECO:0000269|PubMed:23208712}.
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DR   EMBL; CP017627; AOW29725.1; -; Genomic_DNA.
DR   RefSeq; XP_720639.1; XM_715546.1.
DR   AlphaFoldDB; Q5AG46; -.
DR   GeneID; 3637826; -.
DR   KEGG; cal:CAALFM_C503050CA; -.
DR   CGD; CAL0000184734; PGA58.
DR   VEuPathDB; FungiDB:C5_03050C_A; -.
DR   HOGENOM; CLU_993952_0_0_1; -.
DR   OMA; GPEHTNC; -.
DR   PRO; PR:Q5AG46; -.
DR   Proteomes; UP000000559; Chromosome 5.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..219
FT                   /note="Predicted GPI-anchored protein 58"
FT                   /id="PRO_0000429958"
FT   PROPEP          220..240
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000429959"
FT   REGION          41..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..139
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..196
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           219
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        207
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   240 AA;  22838 MW;  4BB92A37E93937CE CRC64;
     MQFSTLVSLA AVIVSTNAAA LLTQTVESST VVTITSCGPE HTNCPASSPA TPAPAPSASA
     PAPPAPEQPE PSAPAPAPSA PAPEQPEQPA TPATPAAPAT PATPAAPEPS APAPEQPASP
     AAPAPAPSAP APAPEQPEQP AAPTTKEAES TPAPAPSAPA PPAPEQPESA PAPAPSAPAP
     EQPESSPAPA PSAPASVPEQ PASSVSNSTG PSSVPTFEGA AAKQYITGSV AVIAAALLAL