ID   PGA61_CANAL             Reviewed;         223 AA.
AC   Q5A8I6; A0A1D8PQA1;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 2.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Probable cell wall protein PGA61;
DE   AltName: Full=Predicted GPI-anchored protein 61;
DE   Flags: Precursor;
GN   Name=PGA61; OrderedLocusNames=CAALFM_C603860CA;
GN   ORFNames=CaO19.13185, CaO19.5762;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   PREDICTION OF GPI-ANCHOR.
RX   PubMed=12845604; DOI=10.1002/yea.1007;
RA   De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT   "Genome-wide identification of fungal GPI proteins.";
RL   Yeast 20:781-796(2003).
CC   -!- FUNCTION: Probable GPI-anchored cell wall protein that may be involved
CC       in cell wall organization, hyphal growth, as well as in virulence.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}. Membrane
CC       {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
CC   -!- PTM: The GPI-anchor is attached to the protein in the endoplasmic
CC       reticulum and serves to target the protein to the cell surface. There,
CC       the glucosamine-inositol phospholipid moiety is cleaved off and the
CC       GPI-modified mannoprotein is covalently attached via its lipidless GPI
CC       glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IHD1 family. {ECO:0000305}.
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DR   EMBL; CP017628; AOW30313.1; -; Genomic_DNA.
DR   RefSeq; XP_718097.2; XM_713004.2.
DR   AlphaFoldDB; Q5A8I6; -.
DR   GeneID; 3640292; -.
DR   KEGG; cal:CAALFM_C603860CA; -.
DR   CGD; CAL0000195894; PGA61.
DR   VEuPathDB; FungiDB:C6_03860C_A; -.
DR   HOGENOM; CLU_1102657_0_0_1; -.
DR   InParanoid; Q5A8I6; -.
DR   OrthoDB; 1604606at2759; -.
DR   PRO; PR:Q5A8I6; -.
DR   Proteomes; UP000000559; Chromosome 6.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell wall; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..202
FT                   /note="Probable cell wall protein PGA61"
FT                   /id="PRO_0000424745"
FT   PROPEP          203..223
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424746"
FT   REGION          83..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           202
FT                   /note="GPI-anchor amidated asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        25
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        188
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   223 AA;  23182 MW;  B742D2A11AC9FDC2 CRC64;
     MKSGLLLAVI LPVAFAVKKD QQSCNSSCVK VLQKQQESCP SGSDADCLCK LSDSDYWEPL
     TDCDCINPDK KLSASEIKVQ ICGAPSSSST PTSSTETTSS TEAETTEAET TEQPSSSTSS
     NTESSKTTIL ETPSIQELNA ESTTSVITPL TESAVAAVAN TDTSTLIEPQ NTEATPEVAP
     LIQPQLNNGS DLAQVSVQAF ENGAGRAAVI GSGSLLALLL NFI