PGA6_CANAL
ID PGA6_CANAL Reviewed; 219 AA.
AC Q5APJ9; A0A1D8PEI1;
DT 11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Predicted GPI-anchored protein 6;
DE Flags: Precursor;
GN Name=PGA6; Synonyms=CCW12; OrderedLocusNames=CAALFM_C109080CA;
GN ORFNames=CaO19.12229, CaO19.4765;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP PREDICTION OF GPI-ANCHOR.
RX PubMed=12845604; DOI=10.1002/yea.1007;
RA De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT "Genome-wide identification of fungal GPI proteins.";
RL Yeast 20:781-796(2003).
RN [5]
RP INDUCTION.
RX PubMed=15387822; DOI=10.1111/j.1365-2958.2004.04214.x;
RA Lan C.Y., Rodarte G., Murillo L.A., Jones T., Davis R.W., Dungan J.,
RA Newport G., Agabian N.;
RT "Regulatory networks affected by iron availability in Candida albicans.";
RL Mol. Microbiol. 53:1451-1469(2004).
RN [6]
RP INDUCTION.
RX PubMed=15870470; DOI=10.1099/mic.0.27763-0;
RA Zhao X., Oh S.H., Yeater K.M., Hoyer L.L.;
RT "Analysis of the Candida albicans Als2p and Als4p adhesins suggests the
RT potential for compensatory function within the Als family.";
RL Microbiology 151:1619-1630(2005).
RN [7]
RP INDUCTION.
RX PubMed=17660402; DOI=10.1099/mic.0.2007/006163-0;
RA Yeater K.M., Chandra J., Cheng G., Mukherjee P.K., Zhao X.,
RA Rodriguez-Zas S.L., Kwast K.E., Ghannoum M.A., Hoyer L.L.;
RT "Temporal analysis of Candida albicans gene expression during biofilm
RT development.";
RL Microbiology 153:2373-2385(2007).
CC -!- FUNCTION: Probable cell wall protein that participates directly in
CC adhesive cell-cell interactions. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000305}. Membrane
CC {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. Note=Covalently-
CC linked GPI-modified cell wall protein (GPI-CWP).
CC -!- INDUCTION: Up-regulated by high iron, during biofilm development, and
CC upon ALS2 depletion. {ECO:0000269|PubMed:15387822,
CC ECO:0000269|PubMed:15870470, ECO:0000269|PubMed:17660402}.
CC -!- PTM: The GPI-anchor is attached to the protein in the endoplasmic
CC reticulum and serves to target the protein to the cell surface. There,
CC the glucosamine-inositol phospholipid moiety is cleaved off and the
CC GPI-modified mannoprotein is covalently attached via its lipidless GPI
CC glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By
CC similarity). {ECO:0000250}.
CC -!- MISCELLANEOUS: The PGA6 mRNA is transported by SHE3 to the hyphal tips
CC during filamentous growth.
CC -!- SIMILARITY: Belongs to the flocculin family. {ECO:0000305}.
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DR EMBL; CP017623; AOW26542.1; -; Genomic_DNA.
DR RefSeq; XP_723451.1; XM_718358.1.
DR AlphaFoldDB; Q5APJ9; -.
DR STRING; 237561.Q5APJ9; -.
DR GeneID; 3634774; -.
DR KEGG; cal:CAALFM_C109080CA; -.
DR CGD; CAL0000190753; PGA6.
DR VEuPathDB; FungiDB:C1_09080C_A; -.
DR eggNOG; ENOG502S42T; Eukaryota.
DR HOGENOM; CLU_086434_0_0_1; -.
DR InParanoid; Q5APJ9; -.
DR OMA; TEYTTIC; -.
DR OrthoDB; 1633983at2759; -.
DR PRO; PR:Q5APJ9; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR InterPro; IPR025928; Flocculin_t3_rpt.
DR Pfam; PF13928; Flocculin_t3; 2.
PE 1: Evidence at protein level;
KW Cell wall; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..194
FT /note="Predicted GPI-anchored protein 6"
FT /id="PRO_0000424644"
FT PROPEP 195..219
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000424645"
FT LIPID 194
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 219 AA; 22101 MW; 46B537E9649ECBAB CRC64;
MQFQTLLVVA GSLVASTLAV NSTVTEHHTT EITITHCSDN KCATSVAPAV QSVNTVTIEG
VVTEYTTYCP LTASEHKHKE SSSPSSVAPV ASTESVVTTT ISGVHTSYTT YCPLSGSSEA
STVITPGTVA GESSSSSEEV SYVDVTSTPV VESTTDVELT LTAQSTLFTS YANSTGSSSS
SSVVPSANVT TFEGGAVGGA SNQITVGFAA IAGLAAILL
