ID   PGAP2_BOVIN             Reviewed;         254 AA.
AC   A6H7B8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Post-GPI attachment to proteins factor 2;
GN   Name=PGAP2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC       maturation. Required for stable expression of GPI-anchored proteins at
CC       the cell surface (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PGAP2IP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PGAP2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC146186; AAI46187.1; -; mRNA.
DR   RefSeq; NP_001092581.1; NM_001099111.1.
DR   RefSeq; XP_010810970.1; XM_010812668.2.
DR   RefSeq; XP_015330253.1; XM_015474767.1.
DR   AlphaFoldDB; A6H7B8; -.
DR   STRING; 9913.ENSBTAP00000011097; -.
DR   PaxDb; A6H7B8; -.
DR   GeneID; 540520; -.
DR   KEGG; bta:540520; -.
DR   CTD; 27315; -.
DR   eggNOG; KOG3979; Eukaryota.
DR   HOGENOM; CLU_061191_1_0_1; -.
DR   InParanoid; A6H7B8; -.
DR   OrthoDB; 1166083at2759; -.
DR   TreeFam; TF314112; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR   InterPro; IPR039545; PGAP2.
DR   PANTHER; PTHR12892; PTHR12892; 1.
DR   Pfam; PF10277; Frag1; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Golgi apparatus; GPI-anchor biosynthesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..254
FT                   /note="Post-GPI attachment to proteins factor 2"
FT                   /id="PRO_0000326092"
FT   TOPO_DOM        1..23
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..114
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..143
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..185
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..209
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        231..254
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   254 AA;  29349 MW;  FE1141F6E654A3FD CRC64;
     MYQVPLPLDR DGTLVRLRFT LVALVTVCCP LVAFLFCVLW SLLFHFKETT ATHCGVPNYL
     PSVSSAIGGE VPQRYVWRFC IGLHSAPRFL VAFAYWNHYL SCTSPCAGYR PLCRLNFGLN
     VVENVALLVL TYVSSSEDFT IHENAFIVFI ASSLSHMLLT CILWRLTKKH TVSQEDRKSY
     NWKQRLFIIN FVSFFTALAV YFRHNMYCEA GVYTIFAILE YTVVLTNMAF HMTAWWDFGN
     KELLITSQPE EKRF