ID   PGAP2_CAEBR             Reviewed;         263 AA.
AC   A8XST1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 2.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Post-GPI attachment to proteins factor 2;
GN   Name=pgap-2 {ECO:0000312|WormBase:CBG18005};
GN   Synonyms=tag-189 {ECO:0000312|WormBase:CBG18005};
GN   ORFNames=CBG18005 {ECO:0000312|WormBase:CBG18005};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC       maturation. Required for stable expression of GPI-anchored proteins at
CC       the cell surface (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PGAP2 family. {ECO:0000305}.
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DR   EMBL; HE600963; CAP35533.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8XST1; -.
DR   STRING; 6238.CBG18005; -.
DR   EnsemblMetazoa; CBG18005.1; CBG18005.1; WBGene00037503.
DR   WormBase; CBG18005; CBP25893; WBGene00037503; Cbr-pgap-2.
DR   eggNOG; KOG3979; Eukaryota.
DR   HOGENOM; CLU_061191_1_0_1; -.
DR   InParanoid; A8XST1; -.
DR   OMA; DRCEPGV; -.
DR   OrthoDB; 1166083at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR   InterPro; IPR039545; PGAP2.
DR   PANTHER; PTHR12892; PTHR12892; 1.
DR   Pfam; PF10277; Frag1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Golgi apparatus; GPI-anchor biosynthesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..263
FT                   /note="Post-GPI attachment to proteins factor 2"
FT                   /id="PRO_0000326100"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   263 AA;  29591 MW;  BB7B9CA50E0EB204 CRC64;
     MALGEDDILS VPFKYFVFCI GGLPSSALLI CVLLSLFLHF DQATSTHCEV ANWLPSISAA
     VSTYTPEKYI WRILIGLHIG PRLVVAVAFR NFLMSSPLRP YTGSKQFKFL CNIACGLNLL
     ENFFLLALTS ISSSEDHSLH AKCFGGFAIS SIIYMILSTW LFSESGRRRA TNLGERSYEY
     KILGASIFVV CFFLGGYLYW RHNTYCEPGI YTLFALVEYS AVLSNIFFHC TLYYDFHGKN
     IALTSSFGSS HYNLLPTQIE KDT