ID   PGAP2_CAEEL             Reviewed;         263 AA.
AC   Q22141;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Post-GPI attachment to proteins factor 2;
GN   Name=pgap-2 {ECO:0000312|WormBase:T04A8.12};
GN   Synonyms=tag-189 {ECO:0000312|WormBase:T04A8.12};
GN   ORFNames=T04A8.12 {ECO:0000312|WormBase:T04A8.12};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC       maturation. Required for stable expression of GPI-anchored proteins at
CC       the cell surface (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PGAP2 family. {ECO:0000305}.
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DR   EMBL; BX284603; CAA84731.2; -; Genomic_DNA.
DR   PIR; T24430; T24430.
DR   RefSeq; NP_497966.2; NM_065565.4.
DR   AlphaFoldDB; Q22141; -.
DR   STRING; 6239.T04A8.12; -.
DR   TCDB; 9.B.131.1.3; the post-gpi attachment protein (p-gap2) family.
DR   EPD; Q22141; -.
DR   PaxDb; Q22141; -.
DR   PeptideAtlas; Q22141; -.
DR   EnsemblMetazoa; T04A8.12.1; T04A8.12.1; WBGene00007045.
DR   GeneID; 188041; -.
DR   UCSC; T04A8.12; c. elegans.
DR   CTD; 188041; -.
DR   WormBase; T04A8.12; CE43481; WBGene00007045; pgap-2.
DR   eggNOG; KOG3979; Eukaryota.
DR   GeneTree; ENSGT00510000047299; -.
DR   HOGENOM; CLU_061191_1_0_1; -.
DR   InParanoid; Q22141; -.
DR   OMA; TCRLWKS; -.
DR   OrthoDB; 1166083at2759; -.
DR   PhylomeDB; Q22141; -.
DR   PRO; PR:Q22141; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00007045; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR   InterPro; IPR039545; PGAP2.
DR   PANTHER; PTHR12892; PTHR12892; 1.
DR   Pfam; PF10277; Frag1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Golgi apparatus; GPI-anchor biosynthesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..263
FT                   /note="Post-GPI attachment to proteins factor 2"
FT                   /id="PRO_0000326101"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   263 AA;  29577 MW;  C549332B5AA4A814 CRC64;
     MAFGDDDILS IPFKYFVICI GGLPSSALLI CVILSLLLHF DQATSTHCEV ANWLPSISAA
     VSTYTPEKYI WRILIGLHIG PRLVVAIAFR NFLLGSPLRP LTGHKRLRFL CNLACFLNLL
     ENFFLLALTS ISSSEDHSLH AKCFGGFAIC SIIYMLLSTW LFNETGRRTA TNLGQRSHEY
     KILGAAIFVL CFFLGAYLYW RHNTYCEPGI YTLFALVEYS AVLSNIFFHC TLYYDFHGKN
     IVLTSSFGGG HYNLLPTQID KDT