ID   PGAP2_CRIGR             Reviewed;         254 AA.
AC   Q2ABP2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Post-GPI attachment to proteins factor 2;
DE   AltName: Full=FGF receptor-activating protein 1;
GN   Name=Pgap2; Synonyms=Frag1;
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=16407401; DOI=10.1091/mbc.e05-11-1005;
RA   Tashima Y., Taguchi R., Murata C., Ashida H., Kinoshita T., Maeda Y.;
RT   "PGAP2 is essential for correct processing and stable expression of GPI-
RT   anchored proteins.";
RL   Mol. Biol. Cell 17:1410-1420(2006).
CC   -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC       maturation. Required for stable expression of GPI-anchored proteins at
CC       the cell surface. {ECO:0000269|PubMed:16407401}.
CC   -!- SUBUNIT: Interacts with PGAP2IP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PGAP2 family. {ECO:0000305}.
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DR   EMBL; AB236145; BAE80229.1; -; mRNA.
DR   RefSeq; NP_001233740.1; NM_001246811.1.
DR   AlphaFoldDB; Q2ABP2; -.
DR   STRING; 10029.NP_001233740.1; -.
DR   Ensembl; ENSCGRT00001027357; ENSCGRP00001023112; ENSCGRG00001021425.
DR   GeneID; 100689385; -.
DR   KEGG; cge:100689385; -.
DR   CTD; 27315; -.
DR   eggNOG; KOG3979; Eukaryota.
DR   GeneTree; ENSGT00510000047299; -.
DR   OrthoDB; 1166083at2759; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR   InterPro; IPR039545; PGAP2.
DR   PANTHER; PTHR12892; PTHR12892; 1.
DR   Pfam; PF10277; Frag1; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Golgi apparatus; GPI-anchor biosynthesis; Membrane;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..254
FT                   /note="Post-GPI attachment to proteins factor 2"
FT                   /id="PRO_0000326093"
FT   TOPO_DOM        1..23
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..114
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..143
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..185
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..209
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        231..254
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   254 AA;  29426 MW;  989179E11D85B99F CRC64;
     MYQVPLTLDR DGTLVRLRFT MVALITVCCP LVAFLFCILW SLLFHFKETT STHCGVPNYL
     PSVSSAIGGE VPQRYVWRFC IGLHSAPRFL AAFAYWNHYL SCASPCPGYR LLCRLNFSLN
     VVENLALLVL TYVSSSEDFT IHENAFIVFI AASLSYMLLT CILWRLTKKH TVSQEDRKSY
     SWKQRLFIIN FISFFSALAV YFRHNMYCEA GVYTIFAILE YTVVLTNMAF HMTAWWDFGN
     KELLITSQPE EKRF